Impact of ACEI/ARB on clinical outcomes in Chinese patients with COVID-19: a meta-analysis
Chinese Journal of Evidence-Based Medicine
; 22(4):438-443, 2022.
Article
in Chinese
| EMBASE | ID: covidwho-1818644
ABSTRACT
Objective To systematically review the impact of ACEI/ARB (angiotensin converting enzyme inhibitor/angiotensin receptor antagonist) treatment on the clinical outcomes of Chinese patients with COVID-19 infections. Methods PubMed, EMbase, Web of Science, The Cochrane Library, CNKI, WanFang Data, and VIP databases were electronically searched to collect cohort studies on the impact of the treatment with ACEI/ARB on the clinical outcomes of Chinese patients with COVID-19 infections from January 2020 to January 2022. Two reviewers independently screened literature, extracted data, and assessed the risk of bias of the included studies. Then, meta-analysis was performed using RevMan 5.3 software. Results A total of 17 cohort studies involving 4 912 subjects were included. The results of meta-analysis showed that patients who were prescribed ACEI/ARB had shorter hospital stays (SMD=-0.28, 95%CI -0.46 to -0.11, P=0.002) and a lower mortality rate (OR=0.47, 95%CI 0.36 to 0.62, P<0.000 01) than patients who did not take ACEI/ARB. Conclusion Current evidence shows that the use of ACEI/ARB drugs can improve the clinical prognosis of Chinese patients with COVID-19 infections. Due to the limited quality and quantity of the included studies, more high-quality studies are needed to verify the above conclusion.
adult; Chinese; clinical outcome; Cochrane Library; cohort analysis; coronavirus disease 2019; drug combination; Embase; female; hospitalization; human; male; Medline; meta analysis; mortality rate; outcome assessment; prognosis; review; risk assessment; software; systematic review; WanFang Database; Web of Science; angiotensin receptor antagonist; dipeptidyl carboxypeptidase inhibitor
Full text:
Available
Collection:
Databases of international organizations
Database:
EMBASE
Type of study:
Experimental Studies
/
Prognostic study
/
Reviews
Language:
Chinese
Journal:
Chinese Journal of Evidence-Based Medicine
Year:
2022
Document Type:
Article
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