In silico screening of Ziziphus spina-christi (L.) Desf. and Strychnos ligustrine compounds as a protease inhibitor of SARS-CoV-2
Journal of Experimental Biology and Agricultural Sciences
; 9(Suppl. 2):S208-S214, 2021.
Article
in English
| CAB Abstracts | ID: covidwho-1818854
ABSTRACT
Diseases caused by the coronavirus have become an important concern in early 2020. The coronavirus is a new type of virus that is included in the SARS-CoV-2 group. One of the possible mechanisms of SARS-CoV-2 inhibition involves protease receptors inhibition. This research was aimed to in silico screening of Ziziphus spina-christi (L.) Desf., and Strychnos ligustrine active ingredients as the main protease inhibitors of SARS-CoV-2 by assessing the ligand-binding affinity in the binding pocket of SARS-CoV-2 main protease protein. The molecular docking method is generally used to predict the inhibitory site and bonds formation. In the current study, some generally used antiviral compounds from the PDB (Protein Data Bank) were also used to compare the affinity strength of the test compound against the protease receptor (code of 5R7Y). The inhibitory activity against the main protease receptor proven by the ChemPLP score is more negative than the receptor's native ligand and the comparison compounds. Jubanine B, a compound of Z. spina-christi has the most robust inhibition activity on the SARS-CoV-2 protease receptor. Results of this study can be concluded that this can be used to develop as a candidate for traditional medicine against SARS-CoV-2 but still it required some more in vitro and in vivo studies.
Prion, Viral, Bacterial and Fungal Pathogens of Humans [VV210]; Animal and in vitro Models for Pharmaceuticals [VV450]; Non-food/Non-feed Plant Products [SS200]; Biochemistry and Physiology of Microorganisms [ZZ394]; coronavirus disease 2019; proteinases; in vitro; enzymes; proteinase inhibitors; screening; antiviral properties; pathogens; ligands; traditional medicines; biochemical receptors; Severe acute respiratory syndrome coronavirus 2; Ziziphus spina-christi; Severe acute respiratory syndrome-related coronavirus; Betacoronavirus; Coronavirinae; Coronaviridae; Nidovirales; positive-sense ssRNA Viruses; ssRNA Viruses; RNA Viruses; viruses; Ziziphus; Rhamnaceae; Rosales; eudicots; angiosperms; Spermatophyta; plants; eukaryotes; Strychnos ligustrina; SARS-CoV-2; proteases; protease inhibitors; screening tests; anti-viral properties
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Databases of international organizations
Database:
CAB Abstracts
Language:
English
Journal:
Journal of Experimental Biology and Agricultural Sciences
Year:
2021
Document Type:
Article
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