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Alterations of blood monocyte subset distribution and surface phenotype are linked to infection severity in COVID-19 inpatients.
Haschka, David; Petzer, Verena; Burkert, Francesco Robert; Fritsche, Gernot; Wildner, Sophie; Bellmann-Weiler, Rosa; Tymoszuk, Piotr; Weiss, Guenter.
  • Haschka D; Department of Internal Medicine II, Medical University of Innsbruck, Innsbruck, Austria.
  • Petzer V; Department of Internal Medicine V, Medical University of Innsbruck, Innsbruck, Austria.
  • Burkert FR; Department of Internal Medicine II, Medical University of Innsbruck, Innsbruck, Austria.
  • Fritsche G; Department of Internal Medicine II, Medical University of Innsbruck, Innsbruck, Austria.
  • Wildner S; Department of Internal Medicine II, Medical University of Innsbruck, Innsbruck, Austria.
  • Bellmann-Weiler R; Department of Internal Medicine II, Medical University of Innsbruck, Innsbruck, Austria.
  • Tymoszuk P; Department of Internal Medicine II, Medical University of Innsbruck, Innsbruck, Austria.
  • Weiss G; Data Analytics As a Service Tirol, Innsbruck, Austria.
Eur J Immunol ; 52(8): 1285-1296, 2022 08.
Article in English | MEDLINE | ID: covidwho-1819355
ABSTRACT
Severe coronavirus disease 19 (COVID-19) manifests with systemic immediate proinflammatory innate immune activation and altered iron turnover. Iron homeostasis, differentiation, and function of myeloid leukocytes are interconnected. Therefore, we characterized the cellularity, surface marker expression, and iron transporter phenotype of neutrophils and monocyte subsets in COVID-19 patients within 72 h from hospital admission, and analyzed how these parameters relate to infection severity. Between March and November 2020, blood leukocyte samples from hospitalized COVID-19 patients (n = 48) and healthy individuals (n = 7) were analyzed by flow cytometry enabling comparative analysis of 40 features. Inflammation-driven neutrophil expansion, depletion of CD16+ nonclassical monocytes, and changes in surface expression of neutrophil and monocyte CD64 and CD86 were associated with COVID-19 severity. By unsupervised self-organizing map clustering, four patterns of innate myeloid response were identified and linked to varying levels of systemic inflammation, altered cellular iron trafficking and the severity of disease. These alterations of the myeloid leukocyte compartment during acute COVID-19 may be hallmarks of inefficient viral control and immune hyperactivation and may help at risk prediction and treatment optimization.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Monocytes / COVID-19 Type of study: Prognostic study Limits: Humans Language: English Journal: Eur J Immunol Year: 2022 Document Type: Article Affiliation country: Eji.202149680

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Monocytes / COVID-19 Type of study: Prognostic study Limits: Humans Language: English Journal: Eur J Immunol Year: 2022 Document Type: Article Affiliation country: Eji.202149680