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Obesity is a risk factor for decrease in lung function after COVID-19 infection in children with asthma.
Soyak Aytekin, Elif; Sahiner, Umit M; Tuten Dal, Sevda; Unsal, Hilal; Hakverdi, Ozan; Oguz, Berna; Ozsurekci, Yasemin; Sekerel, Bulent E; Soyer, Ozge.
  • Soyak Aytekin E; Department of Pediatric Allergy, Hacettepe University School of Medicine, Ankara, Turkey.
  • Sahiner UM; Department of Pediatric Allergy, Hacettepe University School of Medicine, Ankara, Turkey.
  • Tuten Dal S; Department of Pediatric Allergy, Hacettepe University School of Medicine, Ankara, Turkey.
  • Unsal H; Department of Pediatric Allergy, Hacettepe University School of Medicine, Ankara, Turkey.
  • Hakverdi O; Department of Pediatrics, Hacettepe University School of Medicine, Ankara, Turkey.
  • Oguz B; Department of Radiology, Hacettepe University School of Medicine, Ankara, Turkey.
  • Ozsurekci Y; Department of Pediatric Infectious Disease, Hacettepe University School of Medicine, Ankara, Turkey.
  • Sekerel BE; Department of Pediatric Allergy, Hacettepe University School of Medicine, Ankara, Turkey.
  • Soyer O; Department of Pediatric Allergy, Hacettepe University School of Medicine, Ankara, Turkey.
Pediatr Pulmonol ; 57(7): 1668-1676, 2022 Jul.
Article in English | MEDLINE | ID: covidwho-1819388
ABSTRACT

INTRODUCTION:

It is not clear whether asthma, the most frequent chronic disease in childhood, is a risk for severe SARS-CoV-2 infection in the pediatric population and how SARS-CoV-2 infection affects the lung functions in these patients.

PURPOSE:

We aimed to investigate the course and the consequences of SARS-CoV-2 infection among children with asthma and determine the risk factors for the decline in lung function tests (LFTs).

METHODS:

In this retrospective study, asthmatic children with coronavirus disease 2019 (COVID-19) were compared with a random control group of asthmatic patients without COVID-19. In addition, the clinical course and the effect on LFTs of COVID-19 among children with asthma were also evaluated.

RESULTS:

One hundred eighty-nine patients who had COVID-19, and 792 who did not were included in the study. Fever, fatigue, and cough were the most frequent symptoms during COVID-19. Regarding the severity of COVID-19, 163 patients (87.6%) had a mild clinical condition, 13 (7%) had moderate disease, 1 (0.5%) had severe disease, and 2 had (1.1%) critically ill disease. Two patients were diagnosed with multisystem inflammatory syndrome in children (MIS-C), one patient suffered from pneumothorax. LFTs of the patients before and after COVID-19 infection were analyzed; no significant differences were found in FEV1 % (91.7% vs. 90.9%, p = 0.513), FVC% (89.8% vs. 90.8%, p = 0.502) and FEV1 /FVC (103.1% vs. 100.6%, p = 0.056), while FEF25%-75% values (107.6% vs. 98.4%, p < 0.001) were significantly lower after the COVID-19 infection. Obesity (odds ratio [OR] 3.785, 95% confidence interval [CI] 1.152-12.429, p = 0.028] and having a family history of atopy (OR 3.359, 95% CI 1.168-9.657, p = 0.025] were found to be the independent risk factors for ≥25% decrease in FEF25-75 after COVID-19 infection.

CONCLUSION:

COVID-19 infection leads to dysfunction of the small airways in asthmatic children and obesity is an independent risk factor for a ≥25% decrease in FEF25-75. The long-term effects of COVID-19 infection especially on small airways require close monitoring in children with asthma.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Asthma / COVID-19 Type of study: Diagnostic study / Etiology study / Observational study / Randomized controlled trials / Risk factors Topics: Long Covid Limits: Child / Humans Language: English Journal: Pediatr Pulmonol Journal subject: Pediatrics Year: 2022 Document Type: Article Affiliation country: Ppul.25949

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Asthma / COVID-19 Type of study: Diagnostic study / Etiology study / Observational study / Randomized controlled trials / Risk factors Topics: Long Covid Limits: Child / Humans Language: English Journal: Pediatr Pulmonol Journal subject: Pediatrics Year: 2022 Document Type: Article Affiliation country: Ppul.25949