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Elucidating the role of procalcitonin as a biomarker in hospitalized COVID-19 patients.
Cowman, Kelsie; Rossi, James; Gendlina, Inessa; Guo, Yi; Liu, Sichen; Szymczak, Wendy; Forest, Stefanie K; Wolgast, Lucia; Orner, Erika; Bao, Hongkai; Cervera-Hernandez, Miguel E; Ceniceros, Ashley; Thota, Raja; Pirofski, Liise-Anne; Nori, Priya.
  • Cowman K; Division of Infectious Diseases, Department of Medicine, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, NY, USA; Network Performance Group, Montefiore Medical Center, Bronx, NY, USA. Electronic address: kcowman@montefiore.org.
  • Rossi J; Division of Infectious Diseases, Department of Medicine, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, NY, USA.
  • Gendlina I; Division of Infectious Diseases, Department of Medicine, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, NY, USA.
  • Guo Y; Department of Pharmacy, Montefiore Medical Center, Bronx, NY, USA.
  • Liu S; Department of Medicine, Albert Einstein College of Medicine, Bronx, NY, USA.
  • Szymczak W; Department of Pathology, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY, USA.
  • Forest SK; Department of Pathology, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY, USA.
  • Wolgast L; Department of Pathology, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY, USA.
  • Orner E; Department of Pathology, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY, USA.
  • Bao H; Department of Pharmacy, Montefiore Medical Center, Bronx, NY, USA.
  • Cervera-Hernandez ME; Division of Infectious Diseases, Department of Medicine, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, NY, USA.
  • Ceniceros A; Division of Infectious Diseases, Department of Medicine, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, NY, USA.
  • Thota R; Network Performance Group, Montefiore Medical Center, Bronx, NY, USA.
  • Pirofski LA; Division of Infectious Diseases, Department of Medicine, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, NY, USA; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Montefiore Medical Center, Bronx, NY, USA.
  • Nori P; Division of Infectious Diseases, Department of Medicine, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, NY, USA.
Diagn Microbiol Infect Dis ; 103(4): 115721, 2022 Aug.
Article in English | MEDLINE | ID: covidwho-1819473
ABSTRACT
Our objectives were to evaluate the role of procalcitonin in identifying bacterial co-infections in hospitalized COVID-19 patients and quantify antibiotic prescribing during the 2020 pandemic surge. Hospitalized COVID-19 patients with both a procalcitonin test and blood or respiratory culture sent on admission were included in this retrospective study. Confirmed co-infection was determined by an infectious diseases specialist. In total, 819 patients were included; 335 (41%) had an elevated procalcitonin (>0.5 ng/mL) and of these, 42 (13%) had an initial bacterial co-infection. Positive predictive value of elevated procalcitonin for co-infection was 13% while the negative predictive value was 94%. Ninety-six percent of patients with an elevated procalcitonin received antibiotics (median 6 days of therapy), compared to 82% with low procalcitonin (median 4 days of therapy) (adjusted OR3.3, P < 0.001). We observed elevated initial procalcitonin in many COVID patients without concurrent bacterial co-infections which potentially contributed to antibiotic over-prescribing.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Bacterial Infections / Coinfection / Procalcitonin / COVID-19 Type of study: Diagnostic study / Experimental Studies / Observational study / Prognostic study Topics: Long Covid Limits: Humans Language: English Journal: Diagn Microbiol Infect Dis Year: 2022 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Bacterial Infections / Coinfection / Procalcitonin / COVID-19 Type of study: Diagnostic study / Experimental Studies / Observational study / Prognostic study Topics: Long Covid Limits: Humans Language: English Journal: Diagn Microbiol Infect Dis Year: 2022 Document Type: Article