Plasma Proteomics of COVID-19-Associated Cardiovascular Complications: Implications for Pathophysiology and Therapeutics.
JACC Basic Transl Sci
; 7(5): 425-441, 2022 May.
Article
in English
| MEDLINE | ID: covidwho-1819515
ABSTRACT
To gain insights into the mechanisms driving cardiovascular complications in COVID-19, we performed a case-control plasma proteomics study in COVID-19 patients. Our results identify the senescence-associated secretory phenotype, a marker of biological aging, as the dominant process associated with disease severity and cardiac involvement. FSTL3, an indicator of senescence-promoting Activin/TGFß signaling, and ADAMTS13, the von Willebrand Factor-cleaving protease whose loss-of-function causes microvascular thrombosis, were among the proteins most strongly associated with myocardial stress and injury. Findings were validated in a larger COVID-19 patient cohort and the hamster COVID-19 model, providing new insights into the pathophysiology of COVID-19 cardiovascular complications with therapeutic implications.
ADAMTS13, A Disintegrin And Metalloproteinase with a Thrombospondin type 1 motif, member 13; COVID-19; FSTL3, follistatin-like 3; NT-proBNP, N-terminal proB-type natriuretic peptide; SASP, senescence associated secretory phenotype; TGFß, transforming growth factor beta; hsTnT, high sensitivity troponin T; myocardial injury; proteomics; senescence
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Type of study:
Cohort study
/
Observational study
/
Prognostic study
Language:
English
Journal:
JACC Basic Transl Sci
Year:
2022
Document Type:
Article
Affiliation country:
J.jacbts.2022.01.013
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