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Four cases of audio-vestibular disorders related to immunisation with SARS-CoV-2 mRNA vaccines.
Ekobena, Pierre; Rothuizen, Laura E; Bedussi, Francesca; Guilcher, Pierre; Meylan, Sylvain; Ceschi, Alessandro; Girardin, François; Dao, Kim.
  • Ekobena P; Department of Laboratory Medicine and Pathology, Service of Clinical Pharmacology, Lausanne University Hospital (CHUV) and University of Lausanne, Lausanne, Switzerland.
  • Rothuizen LE; Department of Laboratory Medicine and Pathology, Service of Clinical Pharmacology, Lausanne University Hospital (CHUV) and University of Lausanne, Lausanne, Switzerland.
  • Bedussi F; Division of Clinical Pharmacology and Toxicology, Institute of Pharmacological Sciences of Southern Switzerland, Ente Ospedaliero Cantonale, Lugano, Switzerland.
  • Guilcher P; Department of Otorhinolaryngology, Head & Neck Surgery, Lausanne University Hospital (CHUV) and University of Lausanne, Lausanne, Switzerland.
  • Meylan S; Department of Medicine, Infectious Diseases Service, Lausanne University Hospital (CHUV) and University of Lausanne, Lausanne, Switzerland.
  • Ceschi A; Division of Clinical Pharmacology and Toxicology, Institute of Pharmacological Sciences of Southern Switzerland, Ente Ospedaliero Cantonale, Lugano, Switzerland.
  • Girardin F; Department of Laboratory Medicine and Pathology, Service of Clinical Pharmacology, Lausanne University Hospital (CHUV) and University of Lausanne, Lausanne, Switzerland.
  • Dao K; Department of Laboratory Medicine and Pathology, Service of Clinical Pharmacology, Lausanne University Hospital (CHUV) and University of Lausanne, Lausanne, Switzerland.
Int J Audiol ; : 1-5, 2022 May 05.
Article in English | MEDLINE | ID: covidwho-20235179
ABSTRACT

OBJECTIVE:

To gain medical insight into the clinical course and safety of otolaryngologic disorders following immunisation with severe acute respiratory coronavirus (SARS-CoV-2) mRNA-based vaccines.

DESIGN:

Case description. STUDY SAMPLE We report four cases of transient audio-vestibular symptoms, which occurred shortly after inoculation of two BNT162b2 (Pfizer-BioNTech®) and mRNA-1273 (Moderna®) vaccines.

RESULTS:

Hearing loss was unilateral in all cases and recovered at least partially it was associated with persistent gait instability in two cases, after 1 and 7 months. Trigger mechanisms underpinning audio-vestibular impairment remain uncertain. Immune tolerance mechanisms with off-target innate activation of T-lymphocytes may be involved in vestibulocochlear nerve disorders, as for other cranial nerves involvement.

CONCLUSIONS:

The occurrence of audio-vestibular manifestations following mRNA-based vaccines needs ENT monitoring to support their causality in such rare vaccine-related adverse events. Audio-vestibular disorders appeared of transitory nature, including hearing loss, and should not deter further efforts in large-scale vaccination campaigns against SARS-CoV-2.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Prognostic study Topics: Long Covid / Vaccines Language: English Journal: Int J Audiol Journal subject: Audiology Year: 2022 Document Type: Article Affiliation country: 14992027.2022.2056721

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Prognostic study Topics: Long Covid / Vaccines Language: English Journal: Int J Audiol Journal subject: Audiology Year: 2022 Document Type: Article Affiliation country: 14992027.2022.2056721