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Elevated SARS-CoV-2 in peripheral blood and increased COVID-19 severity in American Indians/Alaska Natives.
Perkins, Douglas J; Yingling, Alexandra V; Cheng, Qiuying; Castillo, Amber; Martinez, Janae; Bradfute, Steven B; Leng, Shuguang; Edwards, Jeremy; Guo, Yan; Mertz, Gregory; Harkins, Michelle; Unruh, Mark; Worsham, Anthony; Lambert, Christophe G; Teixeira, J Pedro; Seidenberg, Phillip; Langsjoen, Jens; Schneider, Kristan; Hurwitz, Ivy.
  • Perkins DJ; Center for Global Health, Department of Internal Medicine, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA.
  • Yingling AV; Center for Global Health, Department of Internal Medicine, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA.
  • Cheng Q; Center for Global Health, Department of Internal Medicine, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA.
  • Castillo A; Center for Global Health, Department of Internal Medicine, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA.
  • Martinez J; Center for Global Health, Department of Internal Medicine, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA.
  • Bradfute SB; Center for Global Health, Department of Internal Medicine, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA.
  • Leng S; Division of Epidemiology, Biostatistics and Preventative Medicine, Department of Internal Medicine, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA.
  • Edwards J; Department of Chemistry and Chemical Biology, University of New Mexico, Albuquerque, NM 87131, USA.
  • Guo Y; Division of Molecular Medicine, Department of Internal Medicine, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA.
  • Mertz G; Center for Global Health, Department of Internal Medicine, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA.
  • Harkins M; Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Internal Medicine, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA.
  • Unruh M; Division of Nephrology, Department of Internal Medicine, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA.
  • Worsham A; Division of Hospital Medicine, Department of Internal Medicine, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA.
  • Lambert CG; Center for Global Health, Department of Internal Medicine, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA.
  • Teixeira JP; Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Internal Medicine, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA.
  • Seidenberg P; Department of Emergency Medicine, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA.
  • Langsjoen J; Division of Hospital Medicine, Department of Internal Medicine, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA.
  • Schneider K; Department of Applied Computer- and Bio-Sciences, University of Applied Sciences, Mittweida 09648, Germany.
  • Hurwitz I; Center for Global Health, Department of Internal Medicine, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA.
Exp Biol Med (Maywood) ; 247(14): 1253-1263, 2022 07.
Article in English | MEDLINE | ID: covidwho-1820101
ABSTRACT
Epidemiological data across the United States show health disparities in COVID-19 infection, hospitalization, and mortality by race/ethnicity. While the association between elevated SARS-CoV-2 viral loads (VLs) (i.e. upper respiratory tract (URT) and peripheral blood (PB)) and increased COVID-19 severity has been reported, data remain largely unavailable for some disproportionately impacted racial/ethnic groups, particularly for American Indian or Alaska Native (AI/AN) populations. As such, we determined the relationship between SARS-CoV-2 VL dynamics and disease severity in a diverse cohort of hospitalized patients. Results presented here are for study participants (n = 94, ages 21-88 years) enrolled in a prospective observational study between May and October 2020 who had SARS-CoV-2 viral clades 20A, C, and G. Based on self-reported race/ethnicity and sample size distribution, the cohort was stratified into two groups (AI/AN, n = 43) and all other races/ethnicities combined (non-AI/AN, n = 51). SARS-CoV-2 VLs were quantified in the URT and PB on days 0-3, 6, 9, and 14. The strongest predictor of severe COVID-19 in the study population was the mean VL in PB (OR = 3.34; P = 2.00 × 10-4). The AI/AN group had the following (1) comparable co-morbidities and admission laboratory values, yet more severe COVID-19 (OR = 4.81; P = 0.014); (2) a 2.1 longer duration of hospital stay (P = 0.023); and (3) higher initial and cumulative PB VLs during severe disease (P = 0.025). Moreover, self-reported race/ethnicity as AI/AN was the strongest predictor of elevated PB VLs (ß = 1.08; P = 6.00 × 10-4) and detection of SARS-CoV-2 in PB (hazard ratio = 3.58; P = 0.004). The findings presented here suggest a strong relationship between PB VL (magnitude and frequency) and severe COVID-19, particularly for the AI/AN group.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Alaskan Natives / COVID-19 Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Limits: Adult / Aged / Humans / Middle aged / Young adult Country/Region as subject: North America Language: English Journal: Exp Biol Med (Maywood) Journal subject: Biology / Physiology / Medicine Year: 2022 Document Type: Article Affiliation country: 15353702221091180

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Alaskan Natives / COVID-19 Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Limits: Adult / Aged / Humans / Middle aged / Young adult Country/Region as subject: North America Language: English Journal: Exp Biol Med (Maywood) Journal subject: Biology / Physiology / Medicine Year: 2022 Document Type: Article Affiliation country: 15353702221091180