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Illness Characteristics of COVID-19 in Children Infected with the SARS-CoV-2 Delta Variant.
Molteni, Erika; Sudre, Carole H; Canas, Liane Dos Santos; Bhopal, Sunil S; Hughes, Robert C; Chen, Liyuan; Deng, Jie; Murray, Benjamin; Kerfoot, Eric; Antonelli, Michela; Graham, Mark; Kläser, Kerstin; May, Anna; Hu, Christina; Pujol, Joan Capdevila; Wolf, Jonathan; Hammers, Alexander; Spector, Timothy D; Ourselin, Sebastien; Modat, Marc; Steves, Claire J; Absoud, Michael; Duncan, Emma L.
  • Molteni E; School of Biomedical Engineering & Imaging Sciences, King's College London, London WC2R 2LS, UK.
  • Sudre CH; School of Biomedical Engineering & Imaging Sciences, King's College London, London WC2R 2LS, UK.
  • Canas LDS; MRC Unit for Lifelong Health and Ageing, Department of Population Health Sciences, University College London, London WC1E 6BT, UK.
  • Bhopal SS; Centre for Medical Image Computing, Department of Computer Science, University College London, London WC1E 6BT, UK.
  • Hughes RC; School of Biomedical Engineering & Imaging Sciences, King's College London, London WC2R 2LS, UK.
  • Chen L; Population Health Sciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE1 7RU, UK.
  • Deng J; Department of Population Health, Faculty of Epidemiology & Population Health, London School of Hygiene & Tropical Medicine, Keppel Street, London WC1E 7HT, UK.
  • Murray B; School of Biomedical Engineering & Imaging Sciences, King's College London, London WC2R 2LS, UK.
  • Kerfoot E; School of Biomedical Engineering & Imaging Sciences, King's College London, London WC2R 2LS, UK.
  • Antonelli M; School of Biomedical Engineering & Imaging Sciences, King's College London, London WC2R 2LS, UK.
  • Graham M; School of Biomedical Engineering & Imaging Sciences, King's College London, London WC2R 2LS, UK.
  • Kläser K; School of Biomedical Engineering & Imaging Sciences, King's College London, London WC2R 2LS, UK.
  • May A; School of Biomedical Engineering & Imaging Sciences, King's College London, London WC2R 2LS, UK.
  • Hu C; School of Biomedical Engineering & Imaging Sciences, King's College London, London WC2R 2LS, UK.
  • Pujol JC; ZOE Limited London, London SE1 7RW, UK.
  • Wolf J; ZOE Limited London, London SE1 7RW, UK.
  • Hammers A; ZOE Limited London, London SE1 7RW, UK.
  • Spector TD; ZOE Limited London, London SE1 7RW, UK.
  • Ourselin S; School of Biomedical Engineering & Imaging Sciences, King's College London, London WC2R 2LS, UK.
  • Modat M; King's College London & Guy's and St Thomas' PET Centre, London WC2R 2LS, UK.
  • Steves CJ; Department of Twin Research and Genetic Epidemiology, King's College London, London WC2R 2LS, UK.
  • Absoud M; School of Biomedical Engineering & Imaging Sciences, King's College London, London WC2R 2LS, UK.
  • Duncan EL; School of Biomedical Engineering & Imaging Sciences, King's College London, London WC2R 2LS, UK.
Children (Basel) ; 9(5)2022 May 03.
Article in English | MEDLINE | ID: covidwho-1820186
ABSTRACT

BACKGROUND:

The Delta (B.1.617.2) SARS-CoV-2 variant was the predominant UK circulating strain between May and November 2021. We investigated whether COVID-19 from Delta infection differed from infection with previous variants in children.

METHODS:

Through the prospective COVID Symptom Study, 109,626 UK school-aged children were proxy-reported between 28 December 2020 and 8 July 2021. We selected all symptomatic children who tested positive for SARS-CoV-2 and were proxy-reported at least weekly, within two timeframes 28 December 2020 to 6 May 2021 (Alpha (B.1.1.7), the main UK circulating variant) and 26 May to 8 July 2021 (Delta, the main UK circulating variant), with all children unvaccinated (as per national policy at the time). We assessed illness profiles (symptom prevalence, duration, and burden), hospital presentation, and presence of long (≥28 day) illness, and calculated odds ratios for symptoms presenting within the first 28 days of illness.

RESULTS:

694 (276 younger (5-11 years), 418 older (12-17 years)) symptomatic children tested positive for SARS-CoV-2 with Alpha infection and 706 (227 younger and 479 older) children with Delta infection. Median illness duration was short with either variant (overall cohort 5 days (IQR 2-9.75) with Alpha, 5 days (IQR 2-9) with Delta). The seven most prevalent symptoms were common to both variants. Symptom burden over the first 28 days was slightly greater with Delta compared with Alpha infection (in younger children, 3 (IQR 2-5) symptoms with Alpha, 4 (IQR 2-7) with Delta; in older children, 5 (IQR 3-8) symptoms with Alpha, 6 (IQR 3-9) with Delta infection ). The odds of presenting several symptoms were higher with Delta than Alpha infection, including headache and fever. Few children presented to hospital, and long illness duration was uncommon, with either variant.

CONCLUSIONS:

COVID-19 in UK school-aged children due to SARS-CoV-2 Delta strain B.1.617.2 resembles illness due to the Alpha variant B.1.1.7., with short duration and similar symptom burden.
Keywords

Full text: Available Collection: International databases Database: MEDLINE Type of study: Cohort study / Observational study / Prognostic study Topics: Long Covid / Variants Language: English Year: 2022 Document Type: Article Affiliation country: Children9050652

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Cohort study / Observational study / Prognostic study Topics: Long Covid / Variants Language: English Year: 2022 Document Type: Article Affiliation country: Children9050652