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Understanding the omicron variant (B.1.1.529) of SARS-CoV-2: Mutational impacts, concerns, and the possible solutions.
Islam, Fahadul; Dhawan, Manish; Nafady, Mohamed H; Emran, Talha Bin; Mitra, Saikat; Choudhary, Om Prakash; Akter, Aklima.
  • Islam F; Department of Pharmacy, Faculty of Allied Health Sciences, Daffodil International University, Dhaka 1207, Bangladesh.
  • Dhawan M; Department of Microbiology, Punjab Agricultural University, Ludhiana,141004, Punjab, India.
  • Nafady MH; Trafford College, Altrincham, Manchester, WA14 5PQ, UK.
  • Emran TB; Faculty of Applied Health Science Technology, Misr University for Science and Technology, Giza 12568, Egypt.
  • Mitra S; Department of Pharmacy, BGC Trust University Bangladesh, Chittagong 4381, Bangladesh.
  • Choudhary OP; Department of Pharmacy, Faculty of Pharmacy, University of Dhaka, Dhaka 1000, Bangladesh.
  • Akter A; Department of Veterinary Anatomy and Histology, College of Veterinary Sciences and Animal Husbandry, Central Agricultural University (I), Selesih, Aizawl, India.
Ann Med Surg (Lond) ; 78: 103737, 2022 Jun.
Article in English | MEDLINE | ID: covidwho-1821120
ABSTRACT
Despite many nations' best efforts to contain the so-called COVID-19 pandemic, the emergence of the SARS-CoV-2 Omicron strain (B.1.1.529) has been identified as a serious concern. After more than two years of COVID-19 pandemic and more than a year of worldwide vaccination efforts, the globe will not be free of COVID-19 variants such as Delta and Omicron variants. According to current statistics, the Omicron variant has more than 30 mutations when contrasted to other VOCs such as Alpha (B.1.1.7), Beta (B.1.351), and Delta (B.1.617.2). High numbers of changes, particularly in the spike protein (S-Protein), raise worries about the virus's capacity to resist pre-existing immunity acquired by vaccination or spontaneous infection and antibody-based therapy. The Omicron variant raised international concerns, resuming travel bans and coming up with many questions about its severity, transmissibility, testing, detection, and vaccines efficiency against it. Additionally, inadequate health care infrastructures and many immunocompromised individuals increase the infection susceptibility. The current status of low vaccination rates will play a significant role in omicron spreading and create a fertile ground for producing new variants. As a result, this article emphasizes the mutational changes and their consequences. In addition, the potential preventing measures have been examined in detail.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Experimental Studies / Prognostic study Topics: Vaccines / Variants Language: English Journal: Ann Med Surg (Lond) Year: 2022 Document Type: Article Affiliation country: J.amsu.2022.103737

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Experimental Studies / Prognostic study Topics: Vaccines / Variants Language: English Journal: Ann Med Surg (Lond) Year: 2022 Document Type: Article Affiliation country: J.amsu.2022.103737