Pro-resolving lipid mediators: regulators of inflammation, metabolism and kidney function.
Nat Rev Nephrol
; 17(11): 725-739, 2021 11.
Article
in English
| MEDLINE | ID: covidwho-1821594
ABSTRACT
Obesity, diabetes mellitus, hypertension and cardiovascular disease are risk factors for chronic kidney disease (CKD) and kidney failure. Chronic, low-grade inflammation is recognized as a major pathogenic mechanism that underlies the association between CKD and obesity, impaired glucose tolerance, insulin resistance and diabetes, through interaction between resident and/or circulating immune cells with parenchymal cells. Thus, considerable interest exists in approaches that target inflammation as a strategy to manage CKD. The initial phase of the inflammatory response to injury or metabolic dysfunction reflects the release of pro-inflammatory mediators including peptides, lipids and cytokines, and the recruitment of leukocytes. In self-limiting inflammation, the evolving inflammatory response is coupled to distinct processes that promote the resolution of inflammation and restore homeostasis. The discovery of endogenously generated lipid mediators - specialized pro-resolving lipid mediators and branched fatty acid esters of hydroxy fatty acids - which promote the resolution of inflammation and attenuate the microvascular and macrovascular complications of obesity and diabetes mellitus highlights novel opportunities for potential therapeutic intervention through the targeting of pro-resolution, rather than anti-inflammatory pathways.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Inflammation Mediators
/
Diabetic Nephropathies
/
Renal Insufficiency, Chronic
/
Lipid Metabolism
/
Inflammation
/
Kidney
/
Lipids
Type of study:
Prognostic study
Limits:
Humans
Language:
English
Journal:
Nat Rev Nephrol
Journal subject:
Nephrology
Year:
2021
Document Type:
Article
Affiliation country:
S41581-021-00454-y
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