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Procalcitonin Is Not a Reliable Biomarker of Bacterial Coinfection in People With Coronavirus Disease 2019 Undergoing Microbiological Investigation at the Time of Hospital Admission.
Relph, Katharine A; Russell, Clark D; Fairfield, Cameron J; Turtle, Lance; de Silva, Thushan I; Siggins, Matthew K; Drake, Thomas M; Thwaites, Ryan S; Abrams, Simon; Moore, Shona C; Hardwick, Hayley E; Oosthuyzen, Wilna; Harrison, Ewen M; Docherty, Annemarie B; Openshaw, Peter J M; Baillie, J Kenneth; Semple, Malcolm G; Ho, Antonia.
  • Relph KA; University of Edinburgh Centre for Inflammation Research, Edinburgh, United Kingdom.
  • Russell CD; University of Edinburgh Centre for Inflammation Research, Edinburgh, United Kingdom.
  • Fairfield CJ; Centre for Medical Informatics, Usher Institute, University of Edinburgh, Edinburgh, United Kingdom.
  • Turtle L; National Institute for Health Research Health Protection Research Unit in Emerging and Zoonotic Infections, Institute of Infection, Veterinary and Ecological Sciences, Faculty of Health and Life Sciences, University of Liverpool, Liverpool, United Kingdom.
  • de Silva TI; Liverpool University Hospitals NHS Foundation Trust, Liverpool, United Kingdom.
  • Siggins MK; South Yorkshire Regional Department of Infection and Tropical Medicine, Sheffield Teaching Hospitals National Health Service Foundation Trust, Sheffield, United Kingdom.
  • Drake TM; Department of Infection, Immunity and Cardiovascular Disease, Medical School, University of Sheffield, Sheffield, United Kingdom.
  • Thwaites RS; National Heart and Lung Institute, Imperial College London, London, United Kingdom.
  • Abrams S; Centre for Medical Informatics, Usher Institute, University of Edinburgh, Edinburgh, United Kingdom.
  • Moore SC; National Heart and Lung Institute, Imperial College London, London, United Kingdom.
  • Hardwick HE; Department of Clinical Infection, Microbiology and Immunology, University of Liverpool, Liverpool, United Kingdom.
  • Oosthuyzen W; National Institute for Health Research Health Protection Research Unit in Emerging and Zoonotic Infections, Institute of Infection, Veterinary and Ecological Sciences, Faculty of Health and Life Sciences, University of Liverpool, Liverpool, United Kingdom.
  • Harrison EM; National Institute for Health Research Health Protection Research Unit in Emerging and Zoonotic Infections, Institute of Infection, Veterinary and Ecological Sciences, Faculty of Health and Life Sciences, University of Liverpool, Liverpool, United Kingdom.
  • Docherty AB; Division of Genetics and Genomics, Roslin Institute, University of Edinburgh, Edinburgh, United Kingdom.
  • Openshaw PJM; Centre for Medical Informatics, Usher Institute, University of Edinburgh, Edinburgh, United Kingdom.
  • Baillie JK; Centre for Medical Informatics, Usher Institute, University of Edinburgh, Edinburgh, United Kingdom.
  • Semple MG; National Heart and Lung Institute, Imperial College London, London, United Kingdom.
  • Ho A; Division of Genetics and Genomics, Roslin Institute, University of Edinburgh, Edinburgh, United Kingdom.
Open Forum Infect Dis ; 9(5): ofac179, 2022 May.
Article in English | MEDLINE | ID: covidwho-1915843
ABSTRACT
Admission procalcitonin measurements and microbiology results were available for 1040 hospitalized adults with coronavirus disease 2019 (from 48 902 included in the International Severe Acute Respiratory and Emerging Infections Consortium World Health Organization Clinical Characterisation Protocol UK study). Although procalcitonin was higher in bacterial coinfection, this was neither clinically significant (median [IQR], 0.33 [0.11-1.70] ng/mL vs 0.24 [0.10-0.90] ng/mL) nor diagnostically useful (area under the receiver operating characteristic curve, 0.56 [95% confidence interval, .51-.60]).
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Prognostic study Language: English Journal: Open Forum Infect Dis Year: 2022 Document Type: Article Affiliation country: Ofid

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Prognostic study Language: English Journal: Open Forum Infect Dis Year: 2022 Document Type: Article Affiliation country: Ofid