The Role of E3 Ligase Pirh2 in Disease.
Cells
; 11(9)2022 04 30.
Article
in English
| MEDLINE | ID: covidwho-1822414
ABSTRACT
The p53-dependent ubiquitin ligase Pirh2 regulates a number of proteins involved in different cancer-associated processes. Targeting the p53 family proteins, Chk2, p27Kip1, Twist1 and others, Pirh2 participates in such cellular processes as proliferation, cell cycle regulation, apoptosis and cellular migration. Thus, it is not surprising that Pirh2 takes part in the initiation and progression of different diseases and pathologies including but not limited to cancer. In this review, we aimed to summarize the available data on Pirh2 regulation, its protein targets and its role in various diseases and pathological processes, thus making the Pirh2 protein a promising therapeutic target.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Tumor Suppressor Protein p53
/
Ubiquitin-Protein Ligases
Language:
English
Year:
2022
Document Type:
Article
Affiliation country:
Cells11091515
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