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Montelukast Inhibits HCoV-OC43 Infection as a Viral Inactivator.
Chen, Yongkang; Wang, Xiaohuan; Shi, Huichun; Zou, Peng.
  • Chen Y; Shanghai Public Health Clinical Center, Fudan University, Shanghai 201508, China.
  • Wang X; Shanghai Public Health Clinical Center, Fudan University, Shanghai 201508, China.
  • Shi H; Shanghai Public Health Clinical Center, Fudan University, Shanghai 201508, China.
  • Zou P; Shanghai Public Health Clinical Center, Fudan University, Shanghai 201508, China.
Viruses ; 14(5)2022 04 21.
Article in English | MEDLINE | ID: covidwho-1822446
ABSTRACT
Coronaviruses (CoVs) consist of a large group of RNA viruses causing various diseases in humans and in lots of animals. Human coronavirus (HCoV) OC43, the prototype of beta-coronavirus discovered in the 1960s, has been circulating in humans for long time, and infection with other emerging strains of beta-coronavirus (SARS-CoV, SARS-CoV-2, and MERS-CoV) can lead to severe illness and death. In this study, we found that montelukast, a leukotriene receptor antagonist, potently inhibited the infection of HCoV-OC43 in distinct cells in a dose- and time- dependent manner. Additionally, the results showed that montelukast induced release of HCoV-OC43 genomic RNA by disrupting the integrity of the viral lipid membrane, and irreversibly inhibited viral infection. Considering the similarity among HCoV-OC43, MERS-CoV, and SARS-CoV-2, it suggests that montelukast may be a potential candidate for the treatment of human beta-coronavirus infection.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Coronavirus OC43, Human / Middle East Respiratory Syndrome Coronavirus / COVID-19 Drug Treatment Limits: Animals Language: English Year: 2022 Document Type: Article Affiliation country: V14050861

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Coronavirus OC43, Human / Middle East Respiratory Syndrome Coronavirus / COVID-19 Drug Treatment Limits: Animals Language: English Year: 2022 Document Type: Article Affiliation country: V14050861