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Association of systemic complications with mortality in coronavirus disease of 2019: A cohort study on intensive care unit patients.
Ashraf, Mohammad Ali; Sherafat, Alireza; Naderi, Zohre; Sami, Ramin; Soltaninejad, Forogh; Khodadadi, Saba; Mashayekhbakhsh, Sanaz; Sharafi, Negar; Ahmadi, Somayeh Haji; Shayganfar, Azin; Zand, Iman; Ajami, Ali; Shirani, Kiana.
  • Ashraf MA; Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran.
  • Sherafat A; Department of Undergraduate, School of Medicine, University of Central Lancashire, Preston, United Kingdom.
  • Naderi Z; Department of Internal Medicine, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
  • Sami R; Department of Internal Medicine, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
  • Soltaninejad F; Department of Internal Medicine, Respiratory Research Center, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
  • Khodadadi S; Department of Undergraduate, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
  • Mashayekhbakhsh S; Department of Undergraduate, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
  • Sharafi N; Department of Undergraduate, School of Medicine, University of Central Lancashire, Preston, United Kingdom.
  • Ahmadi SH; Department of Radiology, Isfahan University of Medical Sciences, Isfahan, Iran.
  • Shayganfar A; Department of Radiology, Isfahan University of Medical Sciences, Isfahan, Iran.
  • Zand I; Department of Cardiology, Isfahan University of Medical Sciences, Isfahan, Iran.
  • Ajami A; Department of Laboratory Health, Isfahan University of Medical Sciences, Isfahan, Iran.
  • Shirani K; Assistant Professor of Infectious Diseases, Infectious Diseases and Tropical Medicine Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
J Res Med Sci ; 27: 34, 2022.
Article in English | MEDLINE | ID: covidwho-1869953
ABSTRACT

Background:

Since the beginning of the coronavirus disease of 2019 (COVID-19) pandemic, concerns raised by the growing number of deaths worldwide. Acute respiratory distress syndrome (ARDS) and extrapulmonary complications can correlate with prognosis in COVID-19 patients. This study evaluated the association of systemic complications with mortality in severely affected COVID-19 patients. Materials and

Methods:

This retrospective study was done on 51 intensive care unit (ICU)-admitted COVID-19 adult patients who were admitted to the ICU ward of Khorshid hospital, affiliated with Isfahan University of Medical Sciences. Only the patients who had a definite hospitalization outcome (dead vs. survivors) were included in the study. Daily clinical and paraclinical records were used to diagnose in-hospital complications in these patients.

Results:

The sample was comprised of 37 males (72.5%) and 14 females (27.4%). The median age of patients was 63 years (Min 20, Max 84), with the mortality rate of 47.1%. In total, 70.6% of patients had at least one coexisting disorder. Chronic kidney disease was associated with the worse outcome (29.16% of dead patients against 3.70 of survived ones). Mechanical ventilation was used in 58.8% of patients. Patients who had received invasive ventilation were more likely to die (87.50% of dead patients against 7.40 of survivors), Complications including sepsis and secondary infections (odds ratio 8.05, confidence interval 2.11-30.63) was the strongest predictors of mortality.

Conclusion:

Complications including sepsis and secondary infections can increase the risk of death in ICU-admitted COVID-19 patients. Therefore, it is substantial that the physicians consider preventing or controlling these complications.
Keywords

Full text: Available Collection: International databases Database: MEDLINE Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study Language: English Journal: J Res Med Sci Year: 2022 Document Type: Article Affiliation country: Jrms.JRMS_1213_20

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study Language: English Journal: J Res Med Sci Year: 2022 Document Type: Article Affiliation country: Jrms.JRMS_1213_20