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Longitudinal Analysis of SARS-CoV-2 Vaccine Breakthrough Infections Reveals Limited Infectious Virus Shedding and Restricted Tissue Distribution.
Ke, Ruian; Martinez, Pamela P; Smith, Rebecca L; Gibson, Laura L; Achenbach, Chad J; McFall, Sally; Qi, Chao; Jacob, Joshua; Dembele, Etienne; Bundy, Camille; Simons, Lacy M; Ozer, Egon A; Hultquist, Judd F; Lorenzo-Redondo, Ramon; Opdycke, Anita K; Hawkins, Claudia; Murphy, Robert L; Mirza, Agha; Conte, Madison; Gallagher, Nicholas; Luo, Chun Huai; Jarrett, Junko; Conte, Abigail; Zhou, Ruifeng; Farjo, Mireille; Rendon, Gloria; Fields, Christopher J; Wang, Leyi; Fredrickson, Richard; Baughman, Melinda E; Chiu, Karen K; Choi, Hannah; Scardina, Kevin R; Owens, Alyssa N; Broach, John; Barton, Bruce; Lazar, Peter; Robinson, Matthew L; Mostafa, Heba H; Manabe, Yukari C; Pekosz, Andrew; McManus, David D; Brooke, Christopher B.
  • Ke R; T-6, Theoretical Biology and Biophysics, Los Alamos National Laboratory, Los Alamos, New Mexico, USA.
  • Martinez PP; Department of Microbiology, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA.
  • Smith RL; Carl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA.
  • Gibson LL; Division of Infectious Diseases and Immunology, Departments of Medicine and Pediatrics, University of Massachusetts Medical School, Worcester, Massachusetts, USA.
  • Achenbach CJ; Division of Infectious Diseases and Immunology, Departments of Medicine and Pediatrics, University of Massachusetts Medical School, Worcester, Massachusetts, USA.
  • McFall S; Center for Innovation in Point-of-Care Technologies for HIV/AIDS at Northwestern University, Evanston, Illinois, USA.
  • Qi C; Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
  • Jacob J; Institute for Global Health, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
  • Dembele E; Institute for Global Health, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
  • Bundy C; Institute for Sexual and Gender Minority Health and Wellbeing, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
  • Simons LM; Institute for Global Health, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
  • Ozer EA; Institute for Global Health, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
  • Hultquist JF; Institute for Global Health, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
  • Lorenzo-Redondo R; Institute for Global Health, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
  • Opdycke AK; Department of Health Service, Northwestern University, Evanston, Illinois, USA.
  • Hawkins C; Institute for Global Health, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
  • Murphy RL; Institute for Global Health, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
  • Mirza A; Division of Infectious Diseases, Department of Medicine, Johns Hopkins School of Medicine, Baltimore, Maryland, USA.
  • Conte M; Division of Infectious Diseases, Department of Medicine, Johns Hopkins School of Medicine, Baltimore, Maryland, USA.
  • Gallagher N; Division of Medical Microbiology, Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
  • Luo CH; Division of Medical Microbiology, Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
  • Jarrett J; Division of Medical Microbiology, Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
  • Conte A; W. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
  • Zhou R; W. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
  • Farjo M; Department of Microbiology, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA.
  • Rendon G; High-Performance Biological Computing at the Roy J. Carver Biotechnology Center, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA.
  • Fields CJ; High-Performance Biological Computing at the Roy J. Carver Biotechnology Center, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA.
  • Wang L; Veterinary Diagnostic Laboratory, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA.
  • Fredrickson R; Veterinary Diagnostic Laboratory, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA.
  • Baughman ME; Carl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA.
  • Chiu KK; Carl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA.
  • Choi H; Carl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA.
  • Scardina KR; Carl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA.
  • Owens AN; Center for Clinical and Translational Research, University of Massachusetts Medical School, Worcester, Massachusetts, USA.
  • Broach J; Division of Infectious Diseases and Immunology, Departments of Medicine and Pediatrics, University of Massachusetts Medical School, Worcester, Massachusetts, USA.
  • Barton B; Division of Biostatistics and Health Services Research, University of Massachusetts Medical School, Worcester, Massachusetts, USA.
  • Lazar P; Division of Biostatistics and Health Services Research, University of Massachusetts Medical School, Worcester, Massachusetts, USA.
  • Robinson ML; Division of Infectious Diseases and Immunology, Departments of Medicine and Pediatrics, University of Massachusetts Medical School, Worcester, Massachusetts, USA.
  • Mostafa HH; Division of Medical Microbiology, Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
  • Manabe YC; Division of Infectious Diseases and Immunology, Departments of Medicine and Pediatrics, University of Massachusetts Medical School, Worcester, Massachusetts, USA.
  • Pekosz A; W. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
  • McManus DD; Division of Infectious Diseases and Immunology, Departments of Medicine and Pediatrics, University of Massachusetts Medical School, Worcester, Massachusetts, USA.
  • Brooke CB; Department of Microbiology, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA.
Open Forum Infect Dis ; 9(7): ofac192, 2022 Jul.
Article in English | MEDLINE | ID: covidwho-1922309
ABSTRACT

Background:

The global effort to vaccinate people against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) during an ongoing pandemic has raised questions about how vaccine breakthrough infections compare with infections in immunologically naive individuals and the potential for vaccinated individuals to transmit the virus.

Methods:

We examined viral dynamics and infectious virus shedding through daily longitudinal sampling in 23 adults infected with SARS-CoV-2 at varying stages of vaccination, including 6 fully vaccinated individuals.

Results:

The durations of both infectious virus shedding and symptoms were significantly reduced in vaccinated individuals compared with unvaccinated individuals. We also observed that breakthrough infections are associated with strong tissue compartmentalization and are only detectable in saliva in some cases.

Conclusions:

Vaccination shortens the duration of time of high transmission potential, minimizes symptom duration, and may restrict tissue dissemination.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Prognostic study Topics: Vaccines Language: English Journal: Open Forum Infect Dis Year: 2022 Document Type: Article Affiliation country: Ofid

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Prognostic study Topics: Vaccines Language: English Journal: Open Forum Infect Dis Year: 2022 Document Type: Article Affiliation country: Ofid