Comparison of clinical outcome between dexamethasone and methyl prednisolone in treatment of moderate to severe COVID-19: a systematic review and meta-analysis
Journal of the Association of Physicians of India
; 70(January):44-49, 2022.
Article
in English
| GIM | ID: covidwho-1824227
ABSTRACT
Objective:
Though systemic corticosteroid is used for treatment of COVID 19, questions regarding the appropriate dose, duration and type of corticosteroid use still remain unanswered. This study aimed to address, whether choice of systemic corticosteroid significantly influences the clinical outcome of COVID 19 patients. Materials andMethods:
Studies reporting the comparison between clinical outcome of dexamethasone and methylprednisolone in treatment of COVID 19 were searched from inception till April, 2021. Random-effect model was used. Odd's ratio (OR) and 95% confidence interval was expressed. I2 statistics used for test of heterogeneity.Result:
Three studies with 373 patients (160 in dexamethasone group and 213 in methyl prednisolone group) were included. Though, statistically significant reduction in all-cause mortality with methyl prednisolone group in comparison to dexamethasone group (OR=1.80, 95%CI 1.08 to 3.01, P=0.02) estimated, sub group analysis of observational studies did not support the finding (OR=1.60, 95% CI 0.88 to 2.92, P=0.12). No significant difference in terms of need for invasive ventilator or intensive care unit (ICU) between the 2 groups. The grade of evidence was very low for both the outcomes. Conclusion and Relevance In the present context, both dexamethasone and methyl prednisolone are equally effective in the management of COVID 19.
16978-57-7; 1879-72-7; 1926-94-9; 2265-67-7; 2392-39-4; 312-93-6; 50-02-2; 55812-90-3; 7743-96-6; 83-43-2; 1107-99-9; 125-02-0; 50-24-8; 5060-55-9; 52-21-1; 630-67-1; clinical aspects; comparisons; coronavirus disease 2019; corticoids; dexamethasone; hospitals; human diseases; intensive care units; meta-analysis; methylprednisolone; mortality; observational studies; prednisolone; risk assessment; systematic reviews; viral diseases; artificial respiration; man; Severe acute respiratory syndrome coronavirus 2; Homo; Hominidae; primates; mammals; vertebrates; Chordata; animals; eukaryotes; Severe acute respiratory syndrome-related coronavirus; Betacoronavirus; Coronavirinae; Coronaviridae; Nidovirales; positive-sense ssRNA Viruses; ssRNA Viruses; RNA Viruses; viruses; clinical picture; corticosteroids; death rate; SARS-CoV-2; viral infections
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Collection:
Databases of international organizations
Database:
GIM
Type of study:
Prognostic study
/
Reviews
/
Systematic review/Meta Analysis
Language:
English
Journal:
Journal of the Association of Physicians of India
Year:
2022
Document Type:
Article
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