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Predictive factors of six-week mortality in critically ill patients with SARS-CoV-2: A multicenter prospective study.
Estella, Á; Garcia Garmendia, J L; de la Fuente, C; Machado Casas, J F; Yuste, M E; Amaya Villar, R; Estecha, M A; Yaguez Mateos, L; Cantón Bulnes, M L; Loza, A; Mora, J; Fernández Ruiz, L; Díez Del Corral Fernández, B; Rojas Amezcua, M; Rodriguez Higueras, M I; Díaz Torres, I; Recuerda Núñez, M; Zaheri Beryanaki, M; Rivera Espinar, F; Matallana Zapata, D F; Moreno Cano, S G; Gimenez Beltrán, B; Muñoz, N; Sainz de Baranda Piñero, A; Bustelo Bueno, P; Moreno Barriga, E; Rios Toro, J J; Pérez Ruiz, M; Gómez González, C; Breval Flores, A; de San José Bermejo Gómez, A; Ruiz Cabello Jimenez, M A; Guerrero Marín, M; Ortega Ordiales, A; Tejero-Aranguren, J; Rodriguez Mejías, C; Gomez de Oña, J; de la Hoz, C; Ocaña Fernández, D; Ibañez Cuadros, S; Garnacho Montero, J.
  • Estella Á; Intensive Care Unit, Hospital Universitario de Jerez, Jerez, Spain. Electronic address: litoestella@hotmail.com.
  • Garcia Garmendia JL; Intensive Care Unit, Hospital San Juan de Dios del Aljarafe, Bormujos, Sevilla, Spain.
  • de la Fuente C; Intensive Care Unit, Hospital Universitario Reina Sofía de Córdoba, Córdoba, Spain.
  • Machado Casas JF; Intensive Care Unit, Hospital Universitario Virgen de las Nieves de Granada, Granada, Spain.
  • Yuste ME; Intensive Care Unit, Hospital Universitario Clínico San Cecilio de Granada, Granada, Spain.
  • Amaya Villar R; Intensive Care Unit, Hospital Universitario Virgen del Rocio de Sevilla, Sevilla, Spain.
  • Estecha MA; Intensive Care Unit, Hospital Universitario Virgen de la Victoria de Málaga, Málaga, Spain.
  • Yaguez Mateos L; Intensive Care Unit, Hospital Universitario de Jaén, Jaén, Spain.
  • Cantón Bulnes ML; Intensive Care Unit, Hospital Universitario Virgen Macarena de Sevilla, Sevilla, Spain.
  • Loza A; Intensive Care Unit, Hospital Universitario Virgen de Valme, Sevilla, Spain.
  • Mora J; Intensive Care Unit, Hospital Universitario Regional de Málaga, Málaga, Spain.
  • Fernández Ruiz L; Intensive Care Unit, Hospital San Juan de la Cruz Úbeda, Úbeda, Jaén, Spain.
  • Díez Del Corral Fernández B; Intensive Care Unit, Hospital Universitario de Jerez, Jerez, Spain.
  • Rojas Amezcua M; Intensive Care Unit, Hospital Infanta Margarita de Cabra, Cabra, Spain.
  • Rodriguez Higueras MI; Intensive Care Unit, Hospital Universitario Torrecárdenas Almería, Almería, Spain.
  • Díaz Torres I; Intensive Care Unit, Hospital Universitario de Puerto Real, Puerto Real, Spain.
  • Recuerda Núñez M; Intensive Care Unit, Hospital Universitario de Puerto Real, Puerto Real, Spain.
  • Zaheri Beryanaki M; Intensive Care Unit, Hospital de Antequera, Antequera, Spain.
  • Rivera Espinar F; Intensive Care Unit, Hospital de Montilla, Montilla, Córdoba, Spain.
  • Matallana Zapata DF; Intensive Care Unit, Hospital Infanta Elena de Huelva, Hospital Quirón Huelva, Huelva, Spain.
  • Moreno Cano SG; Intensive Care Unit, Hospital Universitario de Jerez, Jerez, Spain.
  • Gimenez Beltrán B; Intensive Care Unit, Hospital Universitario de Jerez, Jerez, Spain.
  • Muñoz N; Intensive Care Unit, Hospital de la Cruz Roja de Córdoba, Córdoba, Spain.
  • Sainz de Baranda Piñero A; Intensive Care Unit, Hospital HLA Puerta del Sur de Jerez, Jerez, Spain.
  • Bustelo Bueno P; Intensive Care Unit, Hospital HLA Puerta del Sur de Jerez, Jerez, Spain.
  • Moreno Barriga E; Intensive Care Unit, Hospital Universitario de Puerto Real, Puerto Real, Spain.
  • Rios Toro JJ; Intensive Care Unit, Hospital de Ronda, Ronda, Spain.
  • Pérez Ruiz M; Intensive Care Unit, Hospital Universitario de Jerez, Jerez, Spain.
  • Gómez González C; Intensive Care Unit, Hospital Universitario Virgen del Rocio de Sevilla, Sevilla, Spain.
  • Breval Flores A; Intensive Care Unit, Hospital de la Cruz Roja de Córdoba, Córdoba, Spain.
  • de San José Bermejo Gómez A; Intensive Care Unit, Hospital San Juan de Dios de Córdoba, Córdoba, Spain.
  • Ruiz Cabello Jimenez MA; Intensive Care Unit, Hospital de Pozoblanco, Pozoblanco, Córdoba, Spain.
  • Guerrero Marín M; Intensive Care Unit, Hospital Universitario de Jaén, Jaén, Spain.
  • Ortega Ordiales A; Intensive Care Unit, Hospital Universitario Regional de Málaga, Málaga, Spain.
  • Tejero-Aranguren J; Intensive Care Unit, Hospital Universitario Clínico San Cecilio de Granada, Granada, Spain.
  • Rodriguez Mejías C; Intensive Care Unit, Hospital Universitario Virgen de las Nieves de Granada, Granada, Spain.
  • Gomez de Oña J; Intensive Care Unit, Hospital de Poniente, Almería, Spain.
  • de la Hoz C; Intensive Care Unit, Hospital de Poniente, Almería, Spain.
  • Ocaña Fernández D; Intensive Care Unit, Hospital La Inmaculada Huercal-Overa de Almería, Almería, Spain.
  • Ibañez Cuadros S; Intensive Care Unit, Hospital Universitario de Puerto Real, Puerto Real, Spain.
  • Garnacho Montero J; Intensive Care Unit, Hospital Universitario Virgen de la Macarena Sevilla, Sevilla, Spain.
Med Intensiva (Engl Ed) ; 46(4): 179-191, 2022 04.
Article in English | MEDLINE | ID: covidwho-1829191
ABSTRACT

OBJECTIVE:

The objective of the study is to identify the risk factors associated with mortality at six weeks, especially by analyzing the role of antivirals and munomodulators.

DESIGN:

Prospective descriptive multicenter cohort study.

SETTING:

26 Intensive care units (ICU) from Andalusian region in Spain. PATIENTS OR

PARTICIPANTS:

Consecutive critically ill patients with confirmed SARS-CoV-2 infection were included from March 8 to May 30.

INTERVENTIONS:

None. VARIABLES Variables analyzed were demographic, severity scores and clinical condition. Support therapy, drug and mortality were analyzed. An univariate followed by multivariate Cox regression with propensity score analysis was applied.

RESULTS:

495 patients were enrolled, but 73 of them were excluded for incomplete data. Thus, 422 patients were included in the final analysis. Median age was 63 years and 305 (72.3%) were men. ICU mortality 144/422 34%; 14 days mortality 81/422 (19.2%); 28 days mortality 121/422 (28.7%); 6-week mortality 152/422 36.5%. By multivariable Cox proportional analysis, factors independently associated with 42-day mortality were age, APACHE II score, SOFA score at ICU admission >6, Lactate dehydrogenase at ICU admission >470U/L, Use of vasopressors, extrarenal depuration, %lymphocytes 72h post-ICU admission <6.5%, and thrombocytopenia whereas the use of lopinavir/ritonavir was a protective factor.

CONCLUSION:

Age, APACHE II, SOFA>value of 6 points, along with vasopressor requirements or renal replacement therapy have been identified as predictor factors of mortality at six weeks. Administration of corticosteroids showed no benefits in mortality, as did treatment with tocilizumab. Lopinavir/ritonavir administration is identified as a protective factor.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Type of study: Cohort study / Etiology study / Observational study / Prognostic study Limits: Female / Humans / Infant / Male / Middle aged Language: English Journal: Med Intensiva (Engl Ed) Year: 2022 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Type of study: Cohort study / Etiology study / Observational study / Prognostic study Limits: Female / Humans / Infant / Male / Middle aged Language: English Journal: Med Intensiva (Engl Ed) Year: 2022 Document Type: Article