The EORTC protocol for sentinel lymph node biopsy (SLNB) reveals a high number of nodal nevi and a strong association with nevus-associated melanoma.
Pathol Res Pract
; 233: 153805, 2022 May.
Article
in English
| MEDLINE | ID: covidwho-1829375
ABSTRACT
BACKGROUND:
The diagnosis of nodal nevi (NN) is challenging as they mimic melanoma metastases (MM), with a detection rate mostly ranging between 1% and 11% in sentinel lymph node biopsy (SLNB). Herein, we assessed the incidence of NN and the association with the clinical-pathological features of primary melanoma, adopting the updated European Organisation for Research and Treatment of Cancer (EORTC) protocol for SLNB.METHODS:
All cases of paired melanoma and SLNB were retrospectively evaluated (April 2019-May 2020). Appropriate statistical tests were adopted, with significant variables included in the logistic regression model.RESULTS:
81 patients and a total of 186 lymph nodes (LNs) were included. Eleven patients had only NN and 4 had both NN and MM (18.5%); 29 LNs (15.6%) showed at least one NN and 12 (6.5%) showed more than one NN (a total amount of 43 NN was detected). All NN and none MM stained for p16. NN were associated with age < 60 years (p 0.042), no ulceration (p 0.025) and nevus-associated melanoma (NAM) (p 0.018), with this latter being the only predictor at the logistic regression model (p 0.022).CONCLUSIONS:
The updated EORTC protocol shows a high number of NN and highlights a strong association with NAM.Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Skin Neoplasms
/
Melanoma
/
Nevus
Type of study:
Diagnostic study
/
Experimental Studies
/
Observational study
/
Prognostic study
Limits:
Humans
/
Middle aged
Language:
English
Journal:
Pathol Res Pract
Year:
2022
Document Type:
Article
Affiliation country:
J.prp.2022.153805
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