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The role of antigen-presenting cells in the pathogenesis of COVID-19.
Farzi, Rana; Aghbash, Parisa Shiri; Eslami, Narges; Azadi, Arezou; Shamekh, Ali; Hemmat, Nima; Entezari-Maleki, Taher; Baghi, Hossein Bannazadeh.
  • Farzi R; Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; Infectious and Tropical Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
  • Aghbash PS; Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; Infectious and Tropical Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
  • Eslami N; Infectious and Tropical Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; Drug Applied Research Centre, Tabriz University of Medical Sciences, Tabriz, Iran.
  • Azadi A; Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; Infectious and Tropical Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; Department of Virology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
  • Shamekh A; Infectious and Tropical Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.
  • Hemmat N; Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; Drug Applied Research Centre, Tabriz University of Medical Sciences, Tabriz, Iran.
  • Entezari-Maleki T; Department of Clinical Pharmacy, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran; Cardiovascular Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
  • Baghi HB; Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; Infectious and Tropical Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; Department of Virology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran. Electronic address
Pathol Res Pract ; 233: 153848, 2022 May.
Article in English | MEDLINE | ID: covidwho-1829376
ABSTRACT
Coronavirus Disease 2019 (COVID-19) is one of the three lethal coronavirus outbreaks in the recent two decades and a serious threat to global health all over the world. The principal feature of the COVID-19 infection is the so-called "cytokine storm" exaggerated molecular response to virus distribution, which plays massive tissue and organ injury roles. Immunological treatments, including monoclonal antibodies and vaccines, have been suggested as the main approaches in treating and preventing this disease. Therefore, a proper investigation of the roles of antigen-presenting cells (APCs) in the aforementioned immunological responses appears essential. The present review will provide detailed information about APCs' role in the infection and pathogenesis of SARS-CoV-2 and the effect of monoclonal antibodies in diagnosis and treatment.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Topics: Vaccines Limits: Humans Language: English Journal: Pathol Res Pract Year: 2022 Document Type: Article Affiliation country: J.prp.2022.153848

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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Topics: Vaccines Limits: Humans Language: English Journal: Pathol Res Pract Year: 2022 Document Type: Article Affiliation country: J.prp.2022.153848