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Low-dose radiotherapy for COVID-19 pneumonia and cancer: summary of a recent symposium and future perspectives.
Little, Mark P; Zhang, Wei; van Dusen, Roy; Hamada, Nobuyuki; Bugden, Michelle; Cao, Meiyun; Thomas, Kiersten; Li, Deyang; Wang, Yi; Chandrashekhar, Megha; Khan, Mohammad K; Coleman, C Norman.
  • Little MP; Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Rockville, MD, USA.
  • Zhang W; Radiation Effects Department, UK Health Security Agency (UKHSA), Chilton, UK.
  • van Dusen R; Information Management Services, Silver Spring, MD, USA.
  • Hamada N; Biology and Environmental Chemistry Division, Sustainable System Research Laboratory, Central Research Institute of Electric Power Industry (CRIEPI), Komae, Japan.
  • Bugden M; Radiobiology and Health Branch, Canadian Nuclear Laboratories, Chalk River, Canada.
  • Cao M; Radiobiology and Health Branch, Canadian Nuclear Laboratories, Chalk River, Canada.
  • Thomas K; Radiobiology and Health Branch, Canadian Nuclear Laboratories, Chalk River, Canada.
  • Li D; Radiobiology and Health Branch, Canadian Nuclear Laboratories, Chalk River, Canada.
  • Wang Y; Radiobiology and Health Branch, Canadian Nuclear Laboratories, Chalk River, Canada.
  • Chandrashekhar M; Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, Canada.
  • Khan MK; Radiobiology and Health Branch, Canadian Nuclear Laboratories, Chalk River, Canada.
  • Coleman CN; Department of Radiation Oncology, Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA, USA.
Int J Radiat Biol ; : 1-15, 2022 May 26.
Article in English | MEDLINE | ID: covidwho-2232594
ABSTRACT
The lessons learned from the Coronavirus Disease 2019 (COVID-19) pandemic are numerous. Low dose radiotherapy (LDRT) was used in the pre-antibiotic era as treatment for bacterially/virally associated pneumonia. Motivated in part by these historic clinical and radiobiological data, LDRT for treatment of COVID-19-associated pneumonia was proposed in early 2020. Although there is a large body of epidemiological and experimental data pointing to effects such as cancer at low doses, there is some evidence of beneficial health effects at low doses. It has been hypothesized that low dose radiation could be combined with immune checkpoint therapy to treat cancer. We shall review here some of these old radiobiological and epidemiological data, as well as the newer data on low dose radiation and stimulated immune response and other relevant emerging data. The paper includes a summary of several oral presentations given in a Symposium on "Low dose RT for COVID and other inflammatory diseases" as part of the 67th Annual Meeting of the Radiation Research Society, held virtually 3-6 October 2021.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Prognostic study Language: English Journal: Int J Radiat Biol Journal subject: Radiology Year: 2022 Document Type: Article Affiliation country: 09553002.2022.2074165

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Prognostic study Language: English Journal: Int J Radiat Biol Journal subject: Radiology Year: 2022 Document Type: Article Affiliation country: 09553002.2022.2074165