Null IFNAR1 and IFNAR2 alleles are surprisingly common in the Pacific and Arctic.
J Exp Med
; 219(6)2022 06 06.
Article
in English
| MEDLINE | ID: covidwho-1830916
ABSTRACT
In this issue of JEM, Bastard et al. (2022. J. Exp. Med.https//doi.org/10.1084/jem.20220028) show that a loss-of-function IFNAR1 allele is common in western Polynesians, while Duncan et al. (2022. J. Exp. Med.https//doi.org/10.1084/jem.20212427) report that a loss-of-function IFNAR2 allele is common in Inuits. Homozygotes lack type I IFN immunity but are selectively vulnerable to influenza, COVID-19 pneumonia, and complications of live-attenuated viral vaccines.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Receptor, Interferon alpha-beta
Topics:
Vaccines
Limits:
Humans
Language:
English
Year:
2022
Document Type:
Article
Affiliation country:
Jem.20220491
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