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Null IFNAR1 and IFNAR2 alleles are surprisingly common in the Pacific and Arctic.
Meyts, Isabelle.
  • Meyts I; Department of Pediatrics, University Hospitals Leuven, Laboratory for Inborn Errors of Immunity, KU Leuven, Leuven, Belgium.
J Exp Med ; 219(6)2022 06 06.
Article in English | MEDLINE | ID: covidwho-1830916
ABSTRACT
In this issue of JEM, Bastard et al. (2022. J. Exp. Med.https//doi.org/10.1084/jem.20220028) show that a loss-of-function IFNAR1 allele is common in western Polynesians, while Duncan et al. (2022. J. Exp. Med.https//doi.org/10.1084/jem.20212427) report that a loss-of-function IFNAR2 allele is common in Inuits. Homozygotes lack type I IFN immunity but are selectively vulnerable to influenza, COVID-19 pneumonia, and complications of live-attenuated viral vaccines.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Receptor, Interferon alpha-beta Topics: Vaccines Limits: Humans Language: English Year: 2022 Document Type: Article Affiliation country: Jem.20220491

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Receptor, Interferon alpha-beta Topics: Vaccines Limits: Humans Language: English Year: 2022 Document Type: Article Affiliation country: Jem.20220491