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Promoting ß-lactam utilization through suppression of electronic medical record cross-allergy alerts.
Boesch, Teryl S; Eischen, Edward; Ries, Amanda M; Quinn, Andrea; Dave, Ankur; Beezhold, David W.
  • Boesch TS; Northwestern Medicine Palos Hospital, Palos Heights, IL, USA.
  • Eischen E; Northwestern Medicine Palos Hospital, Palos Heights, IL, USA.
  • Ries AM; Northwestern Medicine Palos Hospital, Palos Heights, IL, USA.
  • Quinn A; Northwestern Medicine Palos Hospital, Palos Heights, IL, USA.
  • Dave A; Northwestern Medicine Palos Hospital, Palos Heights, IL, USA.
  • Beezhold DW; Northwestern Medicine Palos Hospital, Palos Heights, IL, USA.
Am J Health Syst Pharm ; 79(Suppl 2): S43-S52, 2022 05 24.
Article in English | MEDLINE | ID: covidwho-1830988
ABSTRACT

PURPOSE:

Current literature surrounding management of patients with reported ß-lactam allergies focuses on allergy delabeling. Standard clinical decision support tools have not been optimized to be compatible with the currently accepted cross-reaction rate of 1% to 2%. This potentially promotes use of non-ß-lactam antibiotics, which are often not first-line therapy and may carry increased risks. The impact of electronic medical record (EMR) clinical decision support tool optimization on utilization of ß-lactam antibiotics in ß-lactam-allergic patients was evaluated.

METHODS:

A retrospective pre-post ß-lactam cross-allergy EMR alert suppression quality improvement intervention cohort study of ß-lactam-allergic adult inpatients prescribed antibiotics was conducted. Preintervention baseline data were collected for an initial cohort admitted during September 2018. The intervention, in which clinical decision support rules were updated to display ß-lactam cross-sensitivity allergy alerts only for ß-lactam-allergic patients with documentation of organization-defined high-severity reactions of anaphylaxis, hives, and shortness of breath, was implemented August 20, 2019. The postintervention cohort included patients admitted during September 2019.

RESULTS:

A 91% increase in the percentage of ß-lactam-allergic patients who received a ß-lactam agent at any time during their admission was noted after the intervention (26.6% vs 51%, P < 0.001). Statistically significant decreases in prescribing of alternative antibiotic classes were seen for fluoroquinolones (decrease from 45.3% to 26%, P < 0.001), aminoglycosides (decrease from 9.4% to 2.9%, P = 0.002), and aztreonam (decrease from 30% to 16.7%, P < 0.001).

CONCLUSION:

EMR ß-lactam cross-allergy alert optimization consistent with current literature significantly improved the utilization of alternative ß-lactam subclasses, mostly through ß-lactam prescribing as initial therapy in ß-lactam-allergic patients.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Beta-Lactams / Drug Hypersensitivity Type of study: Cohort study / Diagnostic study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Limits: Adult / Humans Language: English Journal: Am J Health Syst Pharm Journal subject: Pharmacy / Hospitals Year: 2022 Document Type: Article Affiliation country: Ajhp

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Beta-Lactams / Drug Hypersensitivity Type of study: Cohort study / Diagnostic study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Limits: Adult / Humans Language: English Journal: Am J Health Syst Pharm Journal subject: Pharmacy / Hospitals Year: 2022 Document Type: Article Affiliation country: Ajhp