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Cross-Neutralizing Activity Against Omicron Could Be Obtained in SARS-CoV-2 Convalescent Patients Who Received Two Doses of mRNA Vaccination.
Kurahashi, Yukiya; Furukawa, Koichi; Sutandhio, Silvia; Tjan, Lidya Handayani; Iwata, Sachiyo; Sano, Shigeru; Tohma, Yoshiki; Ohkita, Hiroyuki; Nakamura, Sachiko; Nishimura, Mitsuhiro; Arii, Jun; Kiriu, Tatsunori; Yamamoto, Masatsugu; Nagano, Tatsuya; Nishimura, Yoshihiro; Mori, Yasuko.
  • Kurahashi Y; Division of Clinical Virology, Center for Infectious Diseases, Kobe University Graduate School of Medicine, Kobe, Japan.
  • Furukawa K; Division of Clinical Virology, Center for Infectious Diseases, Kobe University Graduate School of Medicine, Kobe, Japan.
  • Sutandhio S; Division of Clinical Virology, Center for Infectious Diseases, Kobe University Graduate School of Medicine, Kobe, Japan.
  • Tjan LH; Division of Clinical Virology, Center for Infectious Diseases, Kobe University Graduate School of Medicine, Kobe, Japan.
  • Iwata S; Division of Cardiovascular Medicine, Hyogo Prefectural Kakogawa Medical Center, Kakogawa, Japan.
  • Sano S; Acute Care Medical Center, Hyogo Prefectural Kakogawa Medical Center, Kakogawa, Japan.
  • Tohma Y; Acute Care Medical Center, Hyogo Prefectural Kakogawa Medical Center, Kakogawa, Japan.
  • Ohkita H; Division of General Internal Medicine, Hyogo Prefectural Kakogawa Medical Center, Kakogawa, Japan.
  • Nakamura S; Division of General Internal Medicine, Hyogo Prefectural Kakogawa Medical Center, Kakogawa, Japan.
  • Nishimura M; Division of Clinical Virology, Center for Infectious Diseases, Kobe University Graduate School of Medicine, Kobe, Japan.
  • Arii J; Division of Clinical Virology, Center for Infectious Diseases, Kobe University Graduate School of Medicine, Kobe, Japan.
  • Kiriu T; Division of Respiratory Medicine, Hyogo Prefectural Awaji Medical Center, Sumoto, Japan.
  • Yamamoto M; Division of Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan.
  • Nagano T; Division of Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan.
  • Nishimura Y; Kita-Harima Medical Center, Ono, Japan.
  • Mori Y; Division of Clinical Virology, Center for Infectious Diseases, Kobe University Graduate School of Medicine, Kobe, Japan.
J Infect Dis ; 226(8): 1391-1395, 2022 Oct 17.
Article in English | MEDLINE | ID: covidwho-1831182
ABSTRACT
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variant omicron is now under investigation. We evaluated cross-neutralizing activity against omicron in coronavirus disease 2019 (COVID-19) convalescent patients (n = 23) who had received 2 doses of an mRNA vaccination (BNT162b2 or mRNA-1273). Intriguingly, after the second vaccination, the neutralizing antibody titers of subjects against SARS-CoV-2 variants, including omicron, all became seropositive, and significant fold-increases (21.1-52.0) were seen regardless of the disease severity. Our findings thus demonstrate that 2 doses of mRNA vaccination to SARS-CoV-2 convalescent patients can induce cross-neutralizing activity against omicron.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Type of study: Experimental Studies / Prognostic study / Randomized controlled trials Topics: Vaccines / Variants Limits: Humans Language: English Journal: J Infect Dis Year: 2022 Document Type: Article Affiliation country: Infdis

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Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Type of study: Experimental Studies / Prognostic study / Randomized controlled trials Topics: Vaccines / Variants Limits: Humans Language: English Journal: J Infect Dis Year: 2022 Document Type: Article Affiliation country: Infdis