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SARS-CoV-2 Virus Dynamics in Recently Infected People-Data From a Household Transmission Study.
Mellis, Alexandra M; Meece, Jennifer K; Halasa, Natasha B; Chappell, James D; McLean, Huong Q; Grijalva, Carlos G; Hanson, Kayla E; Zhu, Yuwei; Kim, Ahra; Deyoe, Jessica; Ivacic, Lynn C; Reed, Carrie; Talbot, H Keipp; Rolfes, Melissa A.
  • Mellis AM; Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
  • Meece JK; Marshfield Clinic Research Institute, Marshfield, Wisconsin, USA.
  • Halasa NB; Vanderbilt University Medical Center, Nashville, Tennessee, USA.
  • Chappell JD; Vanderbilt University Medical Center, Nashville, Tennessee, USA.
  • McLean HQ; Marshfield Clinic Research Institute, Marshfield, Wisconsin, USA.
  • Grijalva CG; Vanderbilt University Medical Center, Nashville, Tennessee, USA.
  • Hanson KE; Marshfield Clinic Research Institute, Marshfield, Wisconsin, USA.
  • Zhu Y; Vanderbilt University Medical Center, Nashville, Tennessee, USA.
  • Kim A; Vanderbilt University Medical Center, Nashville, Tennessee, USA.
  • Deyoe J; Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
  • Ivacic LC; Marshfield Clinic Research Institute, Marshfield, Wisconsin, USA.
  • Reed C; Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
  • Talbot HK; Vanderbilt University Medical Center, Nashville, Tennessee, USA.
  • Rolfes MA; Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
J Infect Dis ; 226(10): 1699-1703, 2022 Nov 11.
Article in English | MEDLINE | ID: covidwho-1831183
ABSTRACT
We used daily real-time reverse-transcription polymerase chain reaction (RT-PCR) results from 67 cases of SARS-CoV-2 infection in a household transmission study, conducted April 2020-May 2021, to examine the trajectory of cycle threshold (Ct) values, an inverse correlate of viral RNA concentration. Ct values varied across RT-PCR platforms and by participant age. Specimens collected from children and adolescents had higher Ct values and adults aged ≥50 years showed lower Ct values than adults aged 18-49 years. Ct values were lower on days when participants reported experiencing symptoms, with the lowest Ct value occurring 2-6 days after symptom onset.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Type of study: Diagnostic study Limits: Adolescent / Adult / Child / Humans Language: English Journal: J Infect Dis Year: 2022 Document Type: Article Affiliation country: Infdis

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Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Type of study: Diagnostic study Limits: Adolescent / Adult / Child / Humans Language: English Journal: J Infect Dis Year: 2022 Document Type: Article Affiliation country: Infdis