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Waning immunity against respiratory syncytial virus during the COVID-19 pandemic.
Reicherz, Frederic; Xu, Rui Yang; Abu-Raya, Bahaa; Majdoubi, Abdelilah; Michalski, Christina; Golding, Liam; Stojic, Aleksandra; Vineta, Marina; Granoski, Madison; Cieslak, Zenon; Chacko, Anil; Desai, Neil; Sekirov, Inna; Marchant, David J; Lavoie, Pascal M.
  • Reicherz F; British Columbia Children's Hospital Research Institute, Vancouver, Canada.
  • Xu RY; Department of Pediatrics, Faculty of Medicine, University of British Columbia, Vancouver, Canada.
  • Abu-Raya B; British Columbia Children's Hospital Research Institute, Vancouver, Canada.
  • Majdoubi A; Department of Pediatrics, Faculty of Medicine, University of British Columbia, Vancouver, Canada.
  • Michalski C; British Columbia Children's Hospital Research Institute, Vancouver, Canada.
  • Golding L; Department of Pediatrics, Faculty of Medicine, University of British Columbia, Vancouver, Canada.
  • Stojic A; British Columbia Children's Hospital Research Institute, Vancouver, Canada.
  • Vineta M; Department of Pediatrics, Faculty of Medicine, University of British Columbia, Vancouver, Canada.
  • Granoski M; British Columbia Children's Hospital Research Institute, Vancouver, Canada.
  • Cieslak Z; Department of Pediatrics, Faculty of Medicine, University of British Columbia, Vancouver, Canada.
  • Chacko A; British Columbia Children's Hospital Research Institute, Vancouver, Canada.
  • Desai N; Reproductive and Developmental Sciences Program, Department of Obstetrics and Gynecology, University of British Columbia, Canada.
  • Sekirov I; Li Ka Shing Institute of Virology, Department of Medical Microbiology and Immunology, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Canada.
  • Marchant DJ; British Columbia Children's Hospital Research Institute, Vancouver, Canada.
  • Lavoie PM; Reproductive and Developmental Sciences Program, Department of Obstetrics and Gynecology, University of British Columbia, Canada.
J Infect Dis ; 2022 May 07.
Article in English | MEDLINE | ID: covidwho-2318535
ABSTRACT
Health jurisdictions have seen a near-disappearance of Respiratory Syncytial Virus (RSV) during the first year of the COVID-19 pandemic. Over a corresponding period, we report a reduction in RSV antibody levels and neutralization in women and infants one year into the COVID-19 pandemic (February - June 2021) compared to earlier in the pandemic (May - June 2020), in British Columbia (BC), Canada. This supports that humoral immunity against RSV is relatively short-lived and its establishment in infants requires repeated viral exposure. Waned immunity in young children may explain the inter-seasonal resurgence of RSV cases in BC as seen also in other countries.
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Full text: Available Collection: International databases Database: MEDLINE Language: English Year: 2022 Document Type: Article Affiliation country: Infdis

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Full text: Available Collection: International databases Database: MEDLINE Language: English Year: 2022 Document Type: Article Affiliation country: Infdis