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Guillain-Barré Syndrome Related and Unrelated to COVID-19: Clinical Follow-Up in the COVID-19 Era.
Masuccio, Fabio Giuseppe; Tipa, Virginia; Invernizzi, Marco; Solaro, Claudio.
  • Masuccio FG; Department of Rehabilitation, C.R.R.F. "Mons. L. Novarese", Loc. Trompone, Moncrivello, Italy.
  • Tipa V; Department of Rehabilitation, C.R.R.F. "Mons. L. Novarese", Loc. Trompone, Moncrivello, Italy.
  • Invernizzi M; Department of Health Sciences, University of Eastern Piedmont, Novara, Italy.
  • Solaro C; Department of Health Sciences, University of Eastern Piedmont, Novara, Italy.
Phys Ther ; 102(6)2022 06 03.
Article in English | MEDLINE | ID: covidwho-1831320
ABSTRACT

OBJECTIVE:

COVID-19 has been associated with neurological complications such as Guillain-Barre syndrome (GBS). Several cases have been reported but without functional outcome data after intensive rehabilitation and medium-term follow-up.

METHODS:

In this observational study, patients were admitted in 2019 and 2020 to inpatient rehabilitation for GBS and were examined using the Barthel index, GBS-Disability Scale, and Medical Research Scale-sum score at admission, discharge, and at least 6 months after onset of symptoms. All the participants received personalized, goal-oriented inpatient rehabilitative treatment for the recovery of self-sufficiency in everyday life.

RESULTS:

Eleven people with GBS-3 cases related to COVID-19-were admitted in 2019 and 2020 to inpatient rehabilitation. Eight patients with GBS not related to COVID-19 experienced a high complication rate during inpatient rehabilitation, with 2 deaths due to sepsis. In this cohort, a higher prevalence than expected of acute motor axonal neuropathy was also detected. The COVID-19-related GBS group did not have any complications. After a mean of 10.11 months (SD = 4.46 months), 55.55% of patients regained autonomous walking.

CONCLUSION:

COVID-19-related GBS appeared to have a better clinical outcome than GBS that was not COVID-19 related. A higher than usual prevalence of acute motor axonal neuropathy form was encountered. More follow-up studies are needed to understand whether the recovery of GBS related to COVID-19 might be different from that of GBS unrelated to COVID-19. IMPACT No data are currently available on the follow-up of GBS in the COVID-19 era and on the functional outcome of those patients. This study provides important information indicating that GBS related to COVID-19 might have a better clinical outcome than GBS unrelated to COVID-19.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Disabled Persons / Guillain-Barre Syndrome / COVID-19 Type of study: Cohort study / Diagnostic study / Observational study / Prognostic study Topics: Long Covid Limits: Humans Language: English Year: 2022 Document Type: Article Affiliation country: Ptj

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Disabled Persons / Guillain-Barre Syndrome / COVID-19 Type of study: Cohort study / Diagnostic study / Observational study / Prognostic study Topics: Long Covid Limits: Humans Language: English Year: 2022 Document Type: Article Affiliation country: Ptj