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SARS-CoV-2 and Prevotella spp.: friend or foe? A systematic literature review.
Tamanai-Shacoori, Zohreh; Le Gall-David, Sandrine; Moussouni, Fouzia; Sweidan, Alaa; Polard, Elisabeth; Bousarghin, Latifa; Jolivet-Gougeon, Anne.
  • Tamanai-Shacoori Z; Univ Rennes, INSERM, INRAE, CHU Rennes, Institut NUMECAN (Nutrition Metabolisms and Cancer), F-35000 Rennes, France.
  • Le Gall-David S; Univ Rennes, INSERM, INRAE, CHU Rennes, Institut NUMECAN (Nutrition Metabolisms and Cancer), F-35000 Rennes, France.
  • Moussouni F; Univ Rennes, INSERM, INRAE, CHU Rennes, Institut NUMECAN (Nutrition Metabolisms and Cancer), F-35000 Rennes, France.
  • Sweidan A; Laboratory of Microbiology, Department of Life and Earth Sciences, Faculty of Sciences, Lebanese University, Hadath Campus, Beirut, Lebanon.
  • Polard E; Teaching Hospital Rennes, Service de Pharmacovigilance, F-35033 Rennes, France.
  • Bousarghin L; Univ Rennes, INSERM, INRAE, CHU Rennes, Institut NUMECAN (Nutrition Metabolisms and Cancer), F-35000 Rennes, France.
  • Jolivet-Gougeon A; Univ Rennes, INSERM, INRAE, CHU Rennes, Institut NUMECAN (Nutrition Metabolisms and Cancer), F-35000 Rennes, France.
J Med Microbiol ; 71(5)2022 May.
Article in English | MEDLINE | ID: covidwho-1831592
ABSTRACT
During this global pandemic of the COVID-19 disease, a lot of information has arisen in the media and online without scientific validation, and among these is the possibility that this disease could be aggravated by a secondary bacterial infection such as Prevotella, as well as the interest or not in using azithromycin, a potentially active antimicrobial agent. The aim of this study was to carry out a systematic literature review, to prove or disprove these allegations by scientific arguments. The search included Medline, PubMed, and Pubtator Central databases for English-language articles published 1999-2021. After removing duplicates, a total of final eligible studies (n=149) were selected. There were more articles showing an increase of Prevotella abundance in the presence of viral infection like that related to Human Immunodeficiency Virus (HIV), Papillomavirus (HPV), Herpesviridae and respiratory virus, highlighting differences according to methodologies and patient groups. The arguments for or against the use of azithromycin are stated in light of the results of the literature, showing the role of intercurrent factors, such as age, drug consumption, the presence of cancer or periodontal diseases. However, clinical trials are lacking to prove the direct link between the presence of Prevotella spp. and a worsening of COVID-19, mainly those using azithromycin alone in this indication.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Coinfection / COVID-19 Type of study: Experimental Studies / Prognostic study / Randomized controlled trials / Reviews / Systematic review/Meta Analysis Limits: Humans Language: English Year: 2022 Document Type: Article Affiliation country: Jmm.0.001520

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Coinfection / COVID-19 Type of study: Experimental Studies / Prognostic study / Randomized controlled trials / Reviews / Systematic review/Meta Analysis Limits: Humans Language: English Year: 2022 Document Type: Article Affiliation country: Jmm.0.001520