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Covid-19 vaccination during the third trimester of pregnancy: rate of vaccination and maternal and neonatal outcomes, a multicentre retrospective cohort study.
Rottenstreich, M; Sela, H Y; Rotem, R; Kadish, E; Wiener-Well, Y; Grisaru-Granovsky, S.
  • Rottenstreich M; Department of Obstetrics & Gynecology, Shaare Zedek Medical Center and Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel.
  • Sela HY; Department of Nursing, Jerusalem College of Technology, Jerusalem, Israel.
  • Rotem R; Department of Obstetrics & Gynecology, Shaare Zedek Medical Center and Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel.
  • Kadish E; Department of Obstetrics & Gynecology, Shaare Zedek Medical Center and Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel.
  • Wiener-Well Y; Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel.
  • Grisaru-Granovsky S; Infectious Disease Unit, Shaare Zedek Medical Center and Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel.
BJOG ; 129(2): 248-255, 2022 01.
Article in English | MEDLINE | ID: covidwho-1831883
ABSTRACT

OBJECTIVE:

To evaluate the impact of Covid-19 vaccination (Pfizer-BioNTech BNT162b2) during the third trimester of pregnancy on maternal and neonatal outcomes.

DESIGN:

A multicentre, retrospective computerised database. POPULATION Women who gave birth at >24 weeks of gestation in Israel, between January and April 2021, with full records of Covid-19 disease and vaccination status.

METHODS:

Women who received two doses of the vaccine were compared with unvaccinated women. Women who were recorded as having disease or a positive Covid-19 polymerase chain reaction (PCR) swab during pregnancy or delivery were excluded from both study groups. Univariate analysis was followed by multivariate logistic regression. MAIN OUTCOME

MEASURES:

Composite adverse maternal outcomes. Secondary outcomes were vaccination rate and composite adverse neonatal outcomes.

RESULTS:

The overall uptake of one or both vaccines was 40.2%; 712 women who received two doses of the Covid-19 vaccine were compared with 1063 unvaccinated women. Maternal composite outcomes were comparable between the groups; however, women who received the vaccine had higher rates of elective caesarean deliveries (CDs) and lower rates of vacuum deliveries. An adjusted multivariable logistic regression analysis demonstrated that Covid-19 vaccination was not associated with maternal composite adverse outcome (aOR 0.8, 95% CI 0.61-1.03); a significant reduction in the risk for neonatal composite adverse outcomes was observed (aOR 0.5, 95% CI 0.36-0.74).

CONCLUSIONS:

In a motivated population covered by a National Health Insurance Plan, we found a 40.2% rate of vaccination for the Covid-19 vaccine during the third trimester of pregnancy, which was not associated with adverse maternal outcomes and, moreover, decreased the risk for neonatal adverse outcomes. TWEETABLE ABSTRACT Covid-19 vaccine during pregnancy is safe for both mother and fetus.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Vaccination / COVID-19 / BNT162 Vaccine Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Topics: Vaccines Limits: Female / Humans / Infant, Newborn / Pregnancy Country/Region as subject: Asia Language: English Journal: BJOG Journal subject: Gynecology / Obstetrics Year: 2022 Document Type: Article Affiliation country: 1471-0528.16941

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Vaccination / COVID-19 / BNT162 Vaccine Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Topics: Vaccines Limits: Female / Humans / Infant, Newborn / Pregnancy Country/Region as subject: Asia Language: English Journal: BJOG Journal subject: Gynecology / Obstetrics Year: 2022 Document Type: Article Affiliation country: 1471-0528.16941