Your browser doesn't support javascript.
Heterologous Ad.26.COV2.S versus homologous BNT162b2/mRNA-1273 as a third dose in solid organ transplant recipients seronegative after two-dose mRNA vaccination.
Chiang, Teresa Py; Alejo, Jennifer L; Mitchell, Jonathan; Kim, Jake D; Abedon, Aura T; Karaba, Andrew H; Thomas, Letitia; Levan, Macey L; Garonzik-Wang, Jacqueline M; Avery, Robin K; Pekosz, Andrew; Clarke, William A; Warren, Daniel S; Tobian, Aaron A R; Massie, Allan B; Segev, Dorry L; Werbel, William A.
  • Chiang TP; Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
  • Alejo JL; Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
  • Mitchell J; Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
  • Kim JD; Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
  • Abedon AT; Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
  • Karaba AH; Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
  • Thomas L; Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
  • Levan ML; Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
  • Garonzik-Wang JM; Department of Acute and Chronic Care, Johns Hopkins University School of Nursing, Baltimore, Maryland, USA.
  • Avery RK; Department of Surgery, NYU Grossman School of Medicine, NYU Langone Health, New York, New York, USA.
  • Pekosz A; Department of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA.
  • Clarke WA; Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
  • Warren DS; Department of Molecular Microbiology and Immunology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland, USA.
  • Tobian AAR; Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
  • Massie AB; Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
  • Segev DL; Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
  • Werbel WA; Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Am J Transplant ; 22(9): 2254-2260, 2022 09.
Article in English | MEDLINE | ID: covidwho-1831928
ABSTRACT
Heterologous vaccination ("mixing platforms") for the third (D3) dose of SARS-CoV-2 vaccine is a potential strategy to improve antibody responses in solid organ transplant recipients (SOTRs), but data are mixed regarding potential differential immunogenicity. We assessed for differences in immunogenicity and tolerability of homologous (BNT162b2 or mRNA-1273; D3-mRNA) versus heterologous (Ad.26.COV2.S; D3-JJ) D3 among 377 SARS-CoV-2-infection naïve SOTRs who remained seronegative after two mRNA vaccines. We measured anti-spike titers and used weighted Poisson regression to evaluate seroconversion and development of high-titers, comparing D3-JJ to D3-mRNA, at 1-, 3-, and 6 month post-D3. 1-month post-D3, seroconversion (63% vs. 52%, p = .3) and development of high-titers (29% vs. 25%, p = .7) were comparable between D3-JJ and D3-mRNA recipients. 3 month post-D3, D3-JJ recipients were 1.4-fold more likely to seroconvert (80% vs. 57%, weighted incidence-rate-ratio wIRR = 1.10 1.401.77 , p = .006) but not more likely to develop high-titers (27% vs. 22%, wIRR = 0.44 0.921.93 , p = .8). 6 month post-D3, D3-JJ recipients were 1.41-fold more likely to seroconvert (88% vs. 59%, wIRR = 1.04 1.411.93 , p = .029) and 2.63-fold more likely to develop high-titers (59% vs. 21%, wIRR = 1.38 2.635.00 , p = .003). There was no differential signal in alloimmune events or reactogenicity between platforms. SOTRs without antibody response after two mRNA vaccines may derive benefit from heterologous Ad.26.COV2.S D3.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Influenza Vaccines / Organ Transplantation / COVID-19 / BNT162 Vaccine / 2019-nCoV Vaccine mRNA-1273 Type of study: Experimental Studies / Observational study Topics: Vaccines Limits: Humans Language: English Journal: Am J Transplant Journal subject: Transplantation Year: 2022 Document Type: Article Affiliation country: Ajt.17061

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Collection: International databases Database: MEDLINE Main subject: Influenza Vaccines / Organ Transplantation / COVID-19 / BNT162 Vaccine / 2019-nCoV Vaccine mRNA-1273 Type of study: Experimental Studies / Observational study Topics: Vaccines Limits: Humans Language: English Journal: Am J Transplant Journal subject: Transplantation Year: 2022 Document Type: Article Affiliation country: Ajt.17061