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ABSTRACT

To test this, we used the hierarchical PBM clustering of 122 HLA class I allotypes (44 HLA-A, 63 HLA-B, and 18 HLA-C) to identify 21 distinct PBM groups. O14 The pre-transplant non-HLA antibody burden predicts the development of histology of antibody-... Aleksandar Senev 1, Bryan Ray 2, Jayasree Hariharan 2, Christine Heylen 2, Marie-Paule Em... 1 KU Leuven, Belgium, 2 Immucor Inc, United States B Correspondence b aleksenev@yahoo.com In this study we aimed to investigate the role of 82 different non-HLA antibodies in the occurrence of histology of ABMR after kidney transplantation. We developed an assay that estimated the binding strength of HLA II-peptide interaction by measuring the cell-surface expression of HLA II-peptide fusion construct. In the present study, we used a newly developed HLA II-peptide interaction assay to identify HLA II-binding regions in SARS-CoV-2 Spike and the mutations that might affect the interaction with HLA II. [Extracted from the article] Copyright of HLA Immune Response Genetics is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full . (Copyright applies to all s.)