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Investigation of SARS-CoV-2 infection in dogs and cats of humans diagnosed with COVID-19 in Rio de Janeiro, Brazil.
Calvet, Guilherme Amaral; Pereira, Sandro Antonio; Ogrzewalska, Maria; Pauvolid-Corrêa, Alex; Resende, Paola Cristina; Tassinari, Wagner de Souza; Costa, Anielle de Pina; Keidel, Lucas Oliveira; da Rocha, Alice Sampaio Barreto; da Silva, Michele Fernanda Borges; Dos Santos, Shanna Araujo; Lima, Ana Beatriz Machado; de Moraes, Isabella Campos Vargas; Mendes Junior, Artur Augusto Velho; Souza, Thiago das Chagas; Martins, Ezequias Batista; Ornellas, Renato Orsini; Corrêa, Maria Lopes; Antonio, Isabela Maria da Silva; Guaraldo, Lusiele; Motta, Fernando do Couto; Brasil, Patrícia; Siqueira, Marilda Mendonça; Gremião, Isabella Dib Ferreira; Menezes, Rodrigo Caldas.
  • Calvet GA; Acute Febrile Illnesses Laboratory, Evandro Chagas National Institute of Infectious Diseases, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil.
  • Pereira SA; Laboratory of Clinical Research on Dermatozoonoses in Domestic Animals, Evandro Chagas National Institute of Infectious Diseases, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil.
  • Ogrzewalska M; Laboratory of Respiratory Viruses and Measles, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil.
  • Pauvolid-Corrêa A; Laboratory of Respiratory Viruses and Measles, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil.
  • Resende PC; SARS-CoV-2 National Reference Laboratory for the Brazilian Ministry of Health and Regional Reference Laboratory in Americas for the Pan-American Health Organization, Brazil.
  • Tassinari WS; Department of Veterinary Integrative Biosciences, Texas A&M University, College Station, Texas, United States of America.
  • Costa AP; Laboratory of Respiratory Viruses and Measles, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil.
  • Keidel LO; SARS-CoV-2 National Reference Laboratory for the Brazilian Ministry of Health and Regional Reference Laboratory in Americas for the Pan-American Health Organization, Brazil.
  • da Rocha ASB; Mathematics Department, Exact Sciences Institute, Federal Rural University of Rio de Janeiro, Rio de Janeiro, Brazil.
  • da Silva MFB; Acute Febrile Illnesses Laboratory, Evandro Chagas National Institute of Infectious Diseases, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil.
  • Dos Santos SA; Laboratory of Clinical Research on Dermatozoonoses in Domestic Animals, Evandro Chagas National Institute of Infectious Diseases, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil.
  • Lima ABM; Laboratory of Respiratory Viruses and Measles, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil.
  • de Moraes ICV; SARS-CoV-2 National Reference Laboratory for the Brazilian Ministry of Health and Regional Reference Laboratory in Americas for the Pan-American Health Organization, Brazil.
  • Mendes Junior AAV; Acute Febrile Illnesses Laboratory, Evandro Chagas National Institute of Infectious Diseases, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil.
  • Souza TDC; Laboratory of Clinical Research on Dermatozoonoses in Domestic Animals, Evandro Chagas National Institute of Infectious Diseases, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil.
  • Martins EB; Laboratory of Respiratory Viruses and Measles, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil.
  • Ornellas RO; SARS-CoV-2 National Reference Laboratory for the Brazilian Ministry of Health and Regional Reference Laboratory in Americas for the Pan-American Health Organization, Brazil.
  • Corrêa ML; Acute Febrile Illnesses Laboratory, Evandro Chagas National Institute of Infectious Diseases, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil.
  • Antonio IMDS; Laboratory of Clinical Research on Dermatozoonoses in Domestic Animals, Evandro Chagas National Institute of Infectious Diseases, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil.
  • Guaraldo L; Laboratory of Respiratory Viruses and Measles, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil.
  • Motta FDC; SARS-CoV-2 National Reference Laboratory for the Brazilian Ministry of Health and Regional Reference Laboratory in Americas for the Pan-American Health Organization, Brazil.
  • Brasil P; Acute Febrile Illnesses Laboratory, Evandro Chagas National Institute of Infectious Diseases, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil.
  • Siqueira MM; Laboratory of Clinical Research on Dermatozoonoses in Domestic Animals, Evandro Chagas National Institute of Infectious Diseases, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil.
  • Gremião IDF; Laboratory of Clinical Research on Dermatozoonoses in Domestic Animals, Evandro Chagas National Institute of Infectious Diseases, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil.
  • Menezes RC; Laboratory of Clinical Research on Dermatozoonoses in Domestic Animals, Evandro Chagas National Institute of Infectious Diseases, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil.
PLoS One ; 16(4): e0250853, 2021.
Article in English | MEDLINE | ID: covidwho-1833535
Semantic information from SemMedBD (by NLM)
1. COVID-19 PROCESS_OF Felis catus
Subject
COVID-19
Predicate
PROCESS_OF
Object
Felis catus
2. COVID-19 PROCESS_OF Canis familiaris
Subject
COVID-19
Predicate
PROCESS_OF
Object
Canis familiaris
3. COVID-19 PROCESS_OF Homo sapiens
Subject
COVID-19
Predicate
PROCESS_OF
Object
Homo sapiens
4. 2019 novel coronavirus PROCESS_OF Households
Subject
2019 novel coronavirus
Predicate
PROCESS_OF
Object
Households
5. COVID-19 PROCESS_OF Patients
Subject
COVID-19
Predicate
PROCESS_OF
Object
Patients
6. Laboratory LOCATION_OF Analysis
Subject
Laboratory
Predicate
LOCATION_OF
Object
Analysis
7. Specific antibody PART_OF 2019 novel coronavirus
Subject
Specific antibody
Predicate
PART_OF
Object
2019 novel coronavirus
8. Antibodie PART_OF C5203676
Subject
Antibodie
Predicate
PART_OF
Object
C5203676
9. Canis familiaris LOCATION_OF Antibodie
Subject
Canis familiaris
Predicate
LOCATION_OF
Object
Antibodie
10. Malaise PROCESS_OF Owner
Subject
Malaise
Predicate
PROCESS_OF
Object
Owner
11. COVID-19 PROCESS_OF Persons
Subject
COVID-19
Predicate
PROCESS_OF
Object
Persons
12. COVID-19 PROCESS_OF Felis catus
Subject
COVID-19
Predicate
PROCESS_OF
Object
Felis catus
13. COVID-19 PROCESS_OF Canis familiaris
Subject
COVID-19
Predicate
PROCESS_OF
Object
Canis familiaris
14. COVID-19 PROCESS_OF Homo sapiens
Subject
COVID-19
Predicate
PROCESS_OF
Object
Homo sapiens
15. 2019 novel coronavirus PROCESS_OF Households
Subject
2019 novel coronavirus
Predicate
PROCESS_OF
Object
Households
16. COVID-19 PROCESS_OF Patients
Subject
COVID-19
Predicate
PROCESS_OF
Object
Patients
17. Laboratory LOCATION_OF Analysis
Subject
Laboratory
Predicate
LOCATION_OF
Object
Analysis
18. Specific antibody PART_OF 2019 novel coronavirus
Subject
Specific antibody
Predicate
PART_OF
Object
2019 novel coronavirus
19. Antibodies, Neutralizing PART_OF 2019 novel coronavirus
Subject
Antibodies, Neutralizing
Predicate
PART_OF
Object
2019 novel coronavirus
20. Canis familiaris LOCATION_OF Antibodies, Neutralizing
Subject
Canis familiaris
Predicate
LOCATION_OF
Object
Antibodies, Neutralizing
21. Malaise PROCESS_OF Owner
Subject
Malaise
Predicate
PROCESS_OF
Object
Owner
22. COVID-19 PROCESS_OF Persons
Subject
COVID-19
Predicate
PROCESS_OF
Object
Persons
ABSTRACT

BACKGROUND:

Infection by SARS-CoV-2 in domestic animals has been related to close contact with humans diagnosed with COVID-19.

Objectives:

To assess the exposure, infection, and persistence by SARS-CoV-2 of dogs and cats living in the same households of humans that tested positive for SARS-CoV-2, and to investigate clinical and laboratory alterations associated with animal infection.

METHODS:

Animals living with COVID-19 patients were longitudinally followed and had nasopharyngeal/oropharyngeal and rectal swabs collected and tested for SARS-CoV-2. Additionally, blood samples were collected for laboratory analysis, and plaque reduction neutralization test (PRNT90) to investigate specific SARS-CoV-2 antibodies.

RESULTS:

Between May and October 2020, 39 pets (29 dogs and 10 cats) of 21 patients were investigated. Nine dogs (31%) and four cats (40%) from 10 (47.6%) households were infected with or seropositive for SARS-CoV-2. Animals tested positive from 11 to 51 days after the human index COVID-19 case onset of symptoms. Three dogs tested positive twice within 14, 30, and 31 days apart. SARS-CoV-2 neutralizing antibodies were detected in one dog (3.4%) and two cats (20%). In this study, six out of thirteen animals either infected with or seropositive for SARS-CoV-2 have developed mild but reversible signs of the disease. Using logistic regression analysis, neutering, and sharing bed with the ill owner were associated with pet infection.

CONCLUSIONS:

The presence and persistence of SARS-CoV-2 infection have been identified in dogs and cats from households with human COVID-19 cases in Rio de Janeiro, Brazil. People with COVID-19 should avoid close contact with their pets during the time of their illness.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Main subject: Pets / COVID-19 Type of study: Diagnostic study / Observational study / Prevalence study / Risk factors Topics: Long Covid Limits: Animals Country/Region as subject: South America / Brazil Language: English Journal: PLoS One Journal subject: Science / Medicine Year: 2021 Document Type: Article Affiliation country: Journal.pone.0250853

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pets / COVID-19 Type of study: Diagnostic study / Observational study / Prevalence study / Risk factors Topics: Long Covid Limits: Animals Country/Region as subject: South America / Brazil Language: English Journal: PLoS One Journal subject: Science / Medicine Year: 2021 Document Type: Article Affiliation country: Journal.pone.0250853