A new biomarker in severe pneumonia associated with coronavirus disease 2019: hypoalbuminemia. A prospective study.
Sao Paulo Med J
; 140(3): 378-383, 2022.
Article
in English
| MEDLINE | ID: covidwho-1833815
ABSTRACT
BACKGROUND:
Effective triage and early detection are very important for controlling and treating coronavirus disease 2019 (COVID-19). Thus, the relationships between hypoalbuminemia and other acute-phase reactants in such cases need to be evaluated.OBJECTIVES:
To investigate the importance of albumin levels in cases of severe pneumonia due to COVID-19. DESIGN ANDSETTING:
Prospective study conducted in Ankara City Hospital (a stage 3 hospital), Turkey.METHODS:
Data from 122 patients diagnosed with pneumonia due to COVID-19 who were admitted to this hospital were analyzed statistically in comparison with date from 60 healthy controls. Three groups were established healthy controls, intubated patients and non-intubated patients. Lung tomography scans from the patients were examined one-by-one. Real-time polymerase chain reaction (RT-PCR) test results were recorded.RESULTS:
Albumin levels were statistically significantly lower in the intubated and non-intubated groups than in the control group, in comparing the three groups (P < 0.01). The other acute-phase reactants, i.e. neutrophil-to-lymphocyte ratio and C-reactive protein levels, were significantly higher in the intubated and non-intubated groups than in the control group (P < 0.05). Albumin levels were also significantly lower in the intubated group than in the non-intubated group (P = 0.02). No differences were detected with regard to other parameters (P > 0.05).CONCLUSIONS:
Hypoalbuminemia may constitute a biomarker indicating the severity of pneumonia due to COVID-19.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Hypoalbuminemia
/
COVID-19
Type of study:
Cohort study
/
Experimental Studies
/
Observational study
/
Prognostic study
/
Randomized controlled trials
Topics:
Long Covid
Limits:
Humans
Language:
English
Journal:
Sao Paulo Med J
Journal subject:
Medicine
Year:
2022
Document Type:
Article
Affiliation country:
1516-3180.2021.0066.R2.16082021
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