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IgA Nephropathy with Gross Hematuria Following COVID-19 mRNA Vaccination.
Nihei, Yoshihito; Kishi, Monami; Suzuki, Hitoshi; Koizumi, Ayako; Yoshida, Maiko; Hamaguchi, Sho; Iwasaki, Masako; Fukuda, Hiromitsu; Takahara, Hisatsugu; Kihara, Masao; Tomita, Shigeki; Suzuki, Yusuke.
  • Nihei Y; Department of Nephrology, Juntendo University Faculty of Medicine, Japan.
  • Kishi M; Department of Human Pathology, Juntendo University School of Medicine, Japan.
  • Suzuki H; Department of Nephrology, Juntendo University Faculty of Medicine, Japan.
  • Koizumi A; Department of Nephrology, Juntendo University Urayasu Hospital, Japan.
  • Yoshida M; Department of Nephrology, Juntendo University Faculty of Medicine, Japan.
  • Hamaguchi S; Department of Nephrology, Juntendo University Faculty of Medicine, Japan.
  • Iwasaki M; Department of Nephrology, Juntendo University Faculty of Medicine, Japan.
  • Fukuda H; Department of Nephrology, Juntendo University Urayasu Hospital, Japan.
  • Takahara H; Department of Nephrology, Juntendo University Urayasu Hospital, Japan.
  • Kihara M; Department of Nephrology, Juntendo University Urayasu Hospital, Japan.
  • Tomita S; Department of Nephrology, Juntendo University Faculty of Medicine, Japan.
  • Suzuki Y; Department of Human Pathology, Juntendo University School of Medicine, Japan.
Intern Med ; 61(7): 1033-1037, 2022 Apr 01.
Article in English | MEDLINE | ID: covidwho-1834090
ABSTRACT
A 28-year-old woman experienced gross hematuria after the administration of the second dose of an messenger ribonucleic acid (mRNA) vaccine (BNT162b2). She was diagnosed with Immunogloblin A nephropathy (IgAN) by a renal biopsy two weeks after vaccination, which revealed a mild increase in mesangial cells and a matrix with co-depositions of galactose-deficient IgA1 and C3 in the mesangial region. The gross hematuria and proteinuria gradually improved without any medication, suggesting that immune activation by the mRNA vaccine may not elicit continuous disease progression of IgAN. Thus, further studies investigating the relationship between mRNA vaccines against COVID-19 and the progression of IgAN should be conducted.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 / Glomerulonephritis, IGA Type of study: Case report / Diagnostic study Topics: Vaccines Limits: Adult / Female / Humans Language: English Journal: Intern Med Journal subject: Internal Medicine Year: 2022 Document Type: Article Affiliation country: Internalmedicine.8787-21

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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 / Glomerulonephritis, IGA Type of study: Case report / Diagnostic study Topics: Vaccines Limits: Adult / Female / Humans Language: English Journal: Intern Med Journal subject: Internal Medicine Year: 2022 Document Type: Article Affiliation country: Internalmedicine.8787-21