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Urinary tubular biomarkers as predictors of death in critically ill patients with COVID-19.
Bezerra, Gabriela F; Meneses, Gdayllon C; Albuquerque, Polianna Lmm; Lopes, Nicole C; Santos, Ranieri Ss; da Silva, Juliana C; Mota, Sandra Mb; Guimarães, Rodrigo R; Guimarães, Fábio R; Guimarães, Álvaro R; Adamian, Caio Mc; de Lima, Paula R; Bandeira, Izabel Cj; Dantas, Márcia Mp; Junior, Geraldo Bs; Oriá, Reinaldo B; Daher, Elizabeth F; Martins, Alice Mc.
  • Bezerra GF; Post-Graduate Program in Pharmacology, School of Medicine, Universidade Federal do Ceará. Fortaleza, Ceará, 60430-275, Brazil.
  • Meneses GC; Medical Sciences Post-Graduate Program, Department of Internal Medicine, School of Medicine, Universidade Federal do Ceará. Fortaleza, Ceará, 60430-140, Brazil.
  • Albuquerque PL; Public Health Post-Graduate Program, School of Medicine, Health Sciences Center, Universidade de Fortaleza. Fortaleza, Ceará, 60811-905, Brazil.
  • Lopes NC; School of Medicine, Health Sciences Center, Universidade de Fortaleza. Fortaleza, Ceará, 60811-905, Brazil.
  • Santos RS; Instituto José Frota (IJF) Hospital, Fortaleza, Ceará, 60025-061, Brazil.
  • da Silva JC; Post-Graduate Program in Pharmacology, School of Medicine, Universidade Federal do Ceará. Fortaleza, Ceará, 60430-275, Brazil.
  • Mota SM; Post-Graduate Program in Pharmacology, School of Medicine, Universidade Federal do Ceará. Fortaleza, Ceará, 60430-275, Brazil.
  • Guimarães RR; Instituto José Frota (IJF) Hospital, Fortaleza, Ceará, 60025-061, Brazil.
  • Guimarães FR; Medical Sciences Post-Graduate Program, Department of Internal Medicine, School of Medicine, Universidade Federal do Ceará. Fortaleza, Ceará, 60430-140, Brazil.
  • Guimarães ÁR; Instituto José Frota (IJF) Hospital, Fortaleza, Ceará, 60025-061, Brazil.
  • Adamian CM; Public Health Post-Graduate Program, School of Medicine, Health Sciences Center, Universidade de Fortaleza. Fortaleza, Ceará, 60811-905, Brazil.
  • de Lima PR; Universidade Estadual do Ceará, Fortaleza, Ceará, 60714-903, Brazil.
  • Bandeira IC; School of Medicine, Hospital Universitário Walter Cantídio, Universidade Federal do Ceará. Fortaleza, Ceará, 60430-372, Brazil.
  • Dantas MM; School of Medicine, Hospital Universitário Walter Cantídio, Universidade Federal do Ceará. Fortaleza, Ceará, 60430-372, Brazil.
  • Junior GB; Medical Sciences Post-Graduate Program, Department of Internal Medicine, School of Medicine, Universidade Federal do Ceará. Fortaleza, Ceará, 60430-140, Brazil.
  • Oriá RB; Medical Sciences Post-Graduate Program, Department of Internal Medicine, School of Medicine, Universidade Federal do Ceará. Fortaleza, Ceará, 60430-140, Brazil.
  • Daher EF; Medical Sciences Post-Graduate Program, Department of Internal Medicine, School of Medicine, Universidade Federal do Ceará. Fortaleza, Ceará, 60430-140, Brazil.
  • Martins AM; Instituto José Frota (IJF) Hospital, Fortaleza, Ceará, 60025-061, Brazil.
Biomark Med ; 16(9): 681-692, 2022 06.
Article in English | MEDLINE | ID: covidwho-1834208
ABSTRACT

Aim:

To evaluate the prediction capacity of urinary biomarkers for death in critically ill patients with COVID-19.

Methods:

This is a prospective study with critically ill patients due to COVID-19 infection. The urinary biomarkers NGAL, KIM-1, MCP-1 and nephrin were quantified on ICU admission.

Results:

There was 40% of death. Urinary nephrin and MCP-1 had no association with death. Tubular biomarkers (proteinuria, NGAL and KIM-1) were predictors of death and cut-off values of them for death were useful in stratify patients with worse prognosis. In a multivariate cox regression analysis, only NGAL remains associated with a two-mount survival chance.

Conclusion:

Kidney tubular biomarkers, mostly urinary NGAL, had useful capacity to predict death in critically ill COVID-19 patients.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Acute Kidney Injury / COVID-19 Type of study: Cohort study / Diagnostic study / Experimental Studies / Observational study / Prognostic study Limits: Humans Language: English Journal: Biomark Med Journal subject: Biochemistry / Medicine Year: 2022 Document Type: Article Affiliation country: Bmm-2021-0631

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Acute Kidney Injury / COVID-19 Type of study: Cohort study / Diagnostic study / Experimental Studies / Observational study / Prognostic study Limits: Humans Language: English Journal: Biomark Med Journal subject: Biochemistry / Medicine Year: 2022 Document Type: Article Affiliation country: Bmm-2021-0631