Your browser doesn't support javascript.
Molecular Basis for Paradoxical Activities of Polymorphonuclear Neutrophils in Inflammation/Anti-Inflammation, Bactericide/Autoimmunity, Pro-Cancer/Anticancer, and Antiviral Infection/SARS-CoV-II-Induced Immunothrombotic Dysregulation.
Wu, Tsai-Hung; Hsieh, Song-Chou; Li, Tsu-Hao; Lu, Cheng-Hsun; Liao, Hsien-Tzung; Shen, Chieh-Yu; Li, Ko-Jen; Wu, Cheng-Han; Kuo, Yu-Min; Tsai, Chang-Youh; Yu, Chia-Li.
  • Wu TH; Division of Nephrology, Taipei Veterans General Hospital, National Yang-Ming Chiao-Tung University, Taipei 11217, Taiwan.
  • Hsieh SC; Department of Internal Medicine, National Taiwan University Hospital, Taipei 10002, Taiwan.
  • Li TH; Division of Allergy, Immunology and Rheumatology, Shin Kong Wu Ho Shi Hospital, Taipei 11101, Taiwan.
  • Lu CH; Institute of Clinical Medicine, National Yang-Ming Chiao-Tung University, Taipei 11217, Taiwan.
  • Liao HT; Department of Internal Medicine, National Taiwan University Hospital, Taipei 10002, Taiwan.
  • Shen CY; Institute of Clinical Medicine, College of Medicine, National Taiwan University, Taipei 10002, Taiwan.
  • Li KJ; Division of Allergy, Immunology and Rheumatology, Taipei Veterans General Hospital, National Yang-Ming Chiao-Tung University, Taipei 11217, Taiwan.
  • Wu CH; Department of Internal Medicine, National Taiwan University Hospital, Taipei 10002, Taiwan.
  • Kuo YM; Institute of Clinical Medicine, College of Medicine, National Taiwan University, Taipei 10002, Taiwan.
  • Tsai CY; Department of Internal Medicine, National Taiwan University Hospital, Taipei 10002, Taiwan.
  • Yu CL; Department of Internal Medicine, National Taiwan University Hospital, Taipei 10002, Taiwan.
Biomedicines ; 10(4)2022 Mar 25.
Article in English | MEDLINE | ID: covidwho-1834702
ABSTRACT
Polymorphonuclear neutrophils (PMNs) are the most abundant white blood cells in the circulation. These cells act as the fast and powerful defenders against environmental pathogenic microbes to protect the body. In addition, these innate inflammatory cells can produce a number of cytokines/chemokines/growth factors for actively participating in the immune network and immune homeostasis. Many novel biological functions including mitogen-induced cell-mediated cytotoxicity (MICC) and antibody-dependent cell-mediated cytotoxicity (ADCC), exocytosis of microvesicles (ectosomes and exosomes), trogocytosis (plasma membrane exchange) and release of neutrophil extracellular traps (NETs) have been successively discovered. Furthermore, recent investigations unveiled that PMNs act as a double-edged sword to exhibit paradoxical activities on pro-inflammation/anti-inflammation, antibacteria/autoimmunity, pro-cancer/anticancer, antiviral infection/COVID-19-induced immunothrombotic dysregulation. The NETs released from PMNs are believed to play a pivotal role in these paradoxical activities, especially in the cytokine storm and immunothrombotic dysregulation in the recent SARS-CoV-2 pandemic. In this review, we would like to discuss in detail the molecular basis for these strange activities of PMNs.
Keywords

Full text: Available Collection: International databases Database: MEDLINE Language: English Year: 2022 Document Type: Article Affiliation country: Biomedicines10040773

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Collection: International databases Database: MEDLINE Language: English Year: 2022 Document Type: Article Affiliation country: Biomedicines10040773