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Association of Low-Grade Glioma Diagnosis and Management Approach with Mental Health Disorders: A MarketScan Analysis 2005-2014.
Bhanja, Debarati; Ba, Djibril; Tuohy, Kyle; Wilding, Hannah; Trifoi, Mara; Padmanaban, Varun; Liu, Guodong; Sughrue, Michael; Zacharia, Brad; Leslie, Douglas; Mansouri, Alireza.
  • Bhanja D; Penn State College of Medicine, Hershey, PA 17033, USA.
  • Ba D; Department of Public Health Sciences, Penn State College of Medicine, Hershey, PA 17033, USA.
  • Tuohy K; Penn State College of Medicine, Hershey, PA 17033, USA.
  • Wilding H; Penn State College of Medicine, Hershey, PA 17033, USA.
  • Trifoi M; Penn State College of Medicine, Hershey, PA 17033, USA.
  • Padmanaban V; Department of Neurosurgery, Penn State College of Medicine, Hershey, PA 17033, USA.
  • Liu G; Department of Public Health Sciences, Penn State College of Medicine, Hershey, PA 17033, USA.
  • Sughrue M; Centre for Minimally Invasive Neurosurgery, Prince of Wales Private Hospital, Randwick, NSW 2031, Australia.
  • Zacharia B; Department of Neurosurgery, Penn State College of Medicine, Hershey, PA 17033, USA.
  • Leslie D; Penn State Cancer Institute, Hershey, PA 17033, USA.
  • Mansouri A; Department of Public Health Sciences, Penn State College of Medicine, Hershey, PA 17033, USA.
Cancers (Basel) ; 14(6)2022 Mar 08.
Article in English | MEDLINE | ID: covidwho-1834714
ABSTRACT
Low-grade gliomas (LGGs) comprise 13-16% of glial tumors. As survival for LGG patients has been gradually improving, it is essential that the effects of diagnosis and disease progression on mental health be considered. This retrospective cohort study queried the IBM Watson Health MarketScan® Database to describe the incidence and prevalence of mental health disorders (MHDs) among LGG patients and identify associated risk factors. Among the 20,432 LGG patients identified, 12,436 (60.9%) had at least one MHD. Of those who never had a prior MHD, as documented in the claims record, 1915 (16.7%) had their first, newly diagnosed MHD within 12 months after LGG diagnosis. Patients who were female (odds ratio (OR), 1.14, 95% confidence intervals (CI), 1.03-1.26), aged 35-44 (OR, 1.20, 95% CI, 1.03-1.39), and experienced glioma-related seizures (OR, 2.19, 95% CI, 1.95-2.47) were significantly associated with MHD incidence. Patients who underwent resection (OR, 2.58, 95% CI, 2.19-3.04) or biopsy (OR, 2.17, 95% CI, 1.68-2.79) were also more likely to develop a MHD compared to patients who did not undergo a first-line surgical treatment. These data support the need for active surveillance, proactive counseling, and management of MHDs in patients with LGG. Impact of surgery on brain networks affecting mood should also be considered.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Cohort study / Observational study / Prognostic study Language: English Year: 2022 Document Type: Article Affiliation country: Cancers14061376

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Cohort study / Observational study / Prognostic study Language: English Year: 2022 Document Type: Article Affiliation country: Cancers14061376