Potential Beneficial Effects of Vitamin K in SARS-CoV-2 Induced Vascular Disease?
Immuno
; 1(1):17, 2021.
Article
in English
| ProQuest Central | ID: covidwho-1834812
ABSTRACT
Prevalent coagulopathy and thromboembolism are observed in severe COVID-19 patients with 40% of COVID-19 mortality being associated with cardiovascular complications. Abnormal coagulation parameters are related to poor prognosis in COVID-19 patients. Victims also displayed presence of extensive thrombosis in infected lungs. Vitamin K is well-known to play an essential role in the coagulation system. Latest study revealed an existing correlation between vitamin K deficiency and COVID-19 severity, highlighting a role of vitamin K, probably via coagulation modulation. In agreement, other recent studies also indicated that anti-coagulant treatments can reduce mortality in severe cases. Altogether, potential mechanisms linking COVID-19 with coagulopathy in which vitamin K may exert its modulating role in coagulation related with disease pathogenesis are established. In this review, we discuss the recent evidence supporting COVID-19 as a vascular disease and explore the potential benefits of using vitamin K against COVID-19 to improve disease outcomes.
Medical Sciences--Allergology And Immunology; COVID-19; SARS-CoV-2; thromboembolism; vascular disease; vitamin K; Infections; Ventilators; Thrombosis; Neutrophils; Cytokine storm; Severe acute respiratory syndrome coronavirus 2; Pulmonary fibrosis; Asymptomatic; Disease; Mortality; Pulmonary embolisms; Blood clots; Viruses; Anticoagulants; Viral infections; Coronaviruses; Lungs; Proteins
Full text:
Available
Collection:
Databases of international organizations
Database:
ProQuest Central
Type of study:
Experimental Studies
Language:
English
Journal:
Immuno
Year:
2021
Document Type:
Article
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