Rescuing Immunosenescence via Non-Specific Vaccination
Immuno
; 1(3):15, 2021.
Article
in English
| ProQuest Central | ID: covidwho-1834815
ABSTRACT
Discrepancies in lifespan and healthy-life span are predisposing populations to an increasing burden of age-related disease. Accumulating evidence implicates aging of the immune system, termed immunosenescence, in the pathogenesis of multiple age-related diseases. Moreover, immune dysregulation in the elderly increases vulnerability to infection and dampens pathogen-specific immune responses following vaccination. The health challenges manifesting from these age related deficits have been dramatically exemplified by the current SARS-CoV-2 pandemic. Approaches to either attenuate or reverse functional markers of immunosenescence are therefore urgently needed. Recent evidence suggests systemic immunomodulation via non-specific vaccination with live-attenuated vaccines may be a promising avenue to at least reduce aged population vulnerability to viral infection. This short review describes current understanding of immunosenescence, the historical and mechanistic basis of vaccine-mediated immunomodulation, and the outstanding questions and challenges required for broad adoption.
Medical Sciences--Allergology And Immunology; non-specific vaccination; BCG; SARS-CoV-2; Infections; Infectious diseases; COVID-19 vaccines; Pathogens; Frailty; Life expectancy; Age; Severe acute respiratory syndrome coronavirus 2; Health care; Mortality; Cytokines; Measles; Morbidity; Poliomyelitis; Coronaviruses; Tuberculosis; Pediatrics; Guinea Bissau
Full text:
Available
Collection:
Databases of international organizations
Database:
ProQuest Central
Topics:
Vaccines
Language:
English
Journal:
Immuno
Year:
2021
Document Type:
Article
Similar
MEDLINE
...
LILACS
LIS