In Vitro Inhibition of Zika Virus Replication with Amantadine and Rimantadine Hydrochlorides
Microbiology Research
; 12(3):727, 2021.
Article
in English
| ProQuest Central | ID: covidwho-1834839
ABSTRACT
Zika virus (ZIKV) is a mosquito-borne flavivirus in which human infection became relevant during recent outbreaks in Latin America due to its unrecognized association with fetal neurological disorders. Currently, there are no approved effective antivirals or vaccines for the treatment or prevention of ZIKV infections. Amantadine and rimantadine are approved antivirals used against susceptible influenza A virus infections that have been shown to have antiviral activity against other viruses, such as dengue virus (DENV). Here, we report the in vitro effectiveness of both amantadine and rimantadine hydrochlorides against ZIKV replication, resulting in a dose-dependent reduction in viral titers of a ZIKV clinical isolate and two different ZIKV reference strains. Additionally, we demonstrate similar in vitro antiviral activity of these drugs against DENV-1 and yellow fever virus (YFV), although at higher drug concentrations for the latter. ZIKV replication was inhibited at drug concentrations well below cytotoxic levels of both compounds, as denoted by the high selectivity indexes obtained with the tested strains. Further work is absolutely needed to determine the potential clinical use of these antivirals against ZIKV infections, but our results suggest the existence of a highly conserved mechanism across flavivirus, susceptible to be blocked by modified more specific adamantane compounds.
Biology--Microbiology; Zika; dengue; yellow fever; antivirals; adamantanes; amantadine; rimantadine; Infections; Software; Vaccines; Zika virus; Regression analysis; Severe acute respiratory syndrome coronavirus 2; FDA approval; Cytotoxicity; Medical research; Influenza; Guillain-Barre syndrome; Coronaviruses; Disease transmission; Drug therapy; Angola; United States--US
Full text:
Available
Collection:
Databases of international organizations
Database:
ProQuest Central
Language:
English
Journal:
Microbiology Research
Year:
2021
Document Type:
Article
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