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Acinetobacter baumannii Isolates from COVID-19 Patients in a Hospital Intensive Care Unit: Molecular Typing and Risk Factors.
Ceparano, Mariateresa; Baccolini, Valentina; Migliara, Giuseppe; Isonne, Claudia; Renzi, Erika; Tufi, Daniela; De Vito, Corrado; De Giusti, Maria; Trancassini, Maria; Alessandri, Francesco; Ceccarelli, Giancarlo; Pugliese, Francesco; Villari, Paolo; Angiulli, Maria; Battellito, Stefania; Bellini, Arianna; Bongiovanni, Andrea; Caivano, Lucilla; Castellani, Marta; Coletti, Monica; Cottarelli, Alessia; D'Agostino, Ludovica; De Giorgi, Andrea; De Marchi, Chiara; Germani, Irma; Giannini, Dara; Mazzeo, Elisa; Orlandi, Shadi; Piattoli, Matteo; Ricci, Eleonora; Siena, Leonardo Maria; Territo, Alessandro; Vrenna, Gianluca; Zanni, Stefano; Marzuillo, Carolina.
  • Ceparano M; Department of Public Health and Infectious Diseases, Sapienza University of Rome, 00185 Rome, Italy.
  • Baccolini V; Department of Public Health and Infectious Diseases, Sapienza University of Rome, 00185 Rome, Italy.
  • Migliara G; Department of Public Health and Infectious Diseases, Sapienza University of Rome, 00185 Rome, Italy.
  • Isonne C; Department of Public Health and Infectious Diseases, Sapienza University of Rome, 00185 Rome, Italy.
  • Renzi E; Department of Public Health and Infectious Diseases, Sapienza University of Rome, 00185 Rome, Italy.
  • Tufi D; Department of Public Health and Infectious Diseases, Sapienza University of Rome, 00185 Rome, Italy.
  • De Vito C; Department of Public Health and Infectious Diseases, Sapienza University of Rome, 00185 Rome, Italy.
  • De Giusti M; Department of Public Health and Infectious Diseases, Sapienza University of Rome, 00185 Rome, Italy.
  • Trancassini M; Department of Public Health and Infectious Diseases, Sapienza University of Rome, 00185 Rome, Italy.
  • Alessandri F; Microbiology and Virology Unit, Umberto I Teaching Hospital, Sapienza University of Rome, 00161 Rome, Italy.
  • Ceccarelli G; Department of Anaesthesia and Intensive Care Medicine, Umberto I Teaching Hospital, Sapienza University of Rome, 00161 Rome, Italy.
  • Pugliese F; Department of Public Health and Infectious Diseases, Sapienza University of Rome, 00185 Rome, Italy.
  • Villari P; Department of Anaesthesia and Intensive Care Medicine, Umberto I Teaching Hospital, Sapienza University of Rome, 00161 Rome, Italy.
  • Angiulli M; Department of General and Specialist Surgery "P. Stefanini", Sapienza University of Rome, 00185 Rome, Italy.
  • Battellito S; Department of Public Health and Infectious Diseases, Sapienza University of Rome, 00185 Rome, Italy.
  • Bellini A; Department of Public Health and Infectious Diseases, Sapienza University of Rome, 00185 Rome, Italy.
  • Bongiovanni A; Department of Public Health and Infectious Diseases, Sapienza University of Rome, 00185 Rome, Italy.
  • Caivano L; Department of Public Health and Infectious Diseases, Sapienza University of Rome, 00185 Rome, Italy.
  • Castellani M; Department of Public Health and Infectious Diseases, Sapienza University of Rome, 00185 Rome, Italy.
  • Coletti M; Department of Molecular Medicine, Sapienza University of Rome, 00185 Rome, Italy.
  • Cottarelli A; Department of Public Health and Infectious Diseases, Sapienza University of Rome, 00185 Rome, Italy.
  • D'Agostino L; Department of Public Health and Infectious Diseases, Sapienza University of Rome, 00185 Rome, Italy.
  • De Giorgi A; Microbiology and Virology Unit, Umberto I Teaching Hospital, Sapienza University of Rome, 00161 Rome, Italy.
  • De Marchi C; Department of Public Health and Infectious Diseases, Sapienza University of Rome, 00185 Rome, Italy.
  • Germani I; Department of Public Health and Infectious Diseases, Sapienza University of Rome, 00185 Rome, Italy.
  • Giannini D; Department of Public Health and Infectious Diseases, Sapienza University of Rome, 00185 Rome, Italy.
  • Mazzeo E; Department of Public Health and Infectious Diseases, Sapienza University of Rome, 00185 Rome, Italy.
  • Orlandi S; Department of Anaesthesia and Intensive Care Medicine, Umberto I Teaching Hospital, Sapienza University of Rome, 00161 Rome, Italy.
  • Piattoli M; Department of Public Health and Infectious Diseases, Sapienza University of Rome, 00185 Rome, Italy.
  • Ricci E; Department of Public Health and Infectious Diseases, Sapienza University of Rome, 00185 Rome, Italy.
  • Siena LM; Department of Public Health and Infectious Diseases, Sapienza University of Rome, 00185 Rome, Italy.
  • Territo A; Department of Anaesthesia and Intensive Care Medicine, Umberto I Teaching Hospital, Sapienza University of Rome, 00161 Rome, Italy.
  • Vrenna G; Department of Public Health and Infectious Diseases, Sapienza University of Rome, 00185 Rome, Italy.
  • Zanni S; Department of Public Health and Infectious Diseases, Sapienza University of Rome, 00185 Rome, Italy.
  • Marzuillo C; Department of Public Health and Infectious Diseases, Sapienza University of Rome, 00185 Rome, Italy.
Microorganisms ; 10(4)2022 Mar 28.
Article in English | MEDLINE | ID: covidwho-1834842
ABSTRACT
Infections caused by Acinetobacter baumannii represent a major concern for intensive care unit (ICU) patients. However, the epidemiology of these infections among COVID-19 patients has not been fully explored. The aims of this study were (i) to characterize the clonal spread of A. baumannii among COVID-19 patients admitted to the ICU of the Umberto I hospital of Rome during the first year of the pandemic and (ii) to identify risk factors for its acquisition. Isolates were analysed by pulsed-field gel electrophoresis, and a multivariable regression model was constructed. Adjusted odds ratios (aORs) and 95% confidence intervals (CIs) were calculated. Overall, 193 patients were included, and 102 strains were analysed. All isolates had highly antibiotic-resistant profiles and derived from two genotypes. The cumulative incidence of A. baumannii acquisition (colonization or infection) was 36.8%. Patients with A. baumannii had higher mortality and length of stay. Multivariable analysis showed that previous carbapenem use was the only risk factor associated with A. baumannii acquisition (aOR 4.15, 95% CI 1.78-9.64). We documented substantial A. baumannii infections and colonization and high levels of clonal transmission. Given the limited treatment options, effective prevention and containment strategies to limit the spread of A. baumannii should be implemented.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Observational study / Prognostic study Language: English Year: 2022 Document Type: Article Affiliation country: Microorganisms10040722

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Observational study / Prognostic study Language: English Year: 2022 Document Type: Article Affiliation country: Microorganisms10040722