Your browser doesn't support javascript.
Cutting Edge: SARS-CoV-2 Infection Induces Robust Germinal Center Activity in the Human Tonsil.
Tan, Hyon-Xhi; Wragg, Kathleen M; Kelly, Hannah G; Esterbauer, Robyn; Dixon, Benjamin J; Lau, Jillian S Y; Flanagan, Katie L; van de Sandt, Carolien E; Kedzierska, Katherine; McMahon, James H; Wheatley, Adam K; Juno, Jennifer A; Kent, Stephen J.
  • Tan HX; Department of Microbiology and Immunology, University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia.
  • Wragg KM; Department of Microbiology and Immunology, University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia.
  • Kelly HG; Department of Microbiology and Immunology, University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia.
  • Esterbauer R; Department of Microbiology and Immunology, University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia.
  • Dixon BJ; Head and Neck Surgery, Epworth Healthcare, Richmond, Victoria, Australia.
  • Lau JSY; Department of Infectious Diseases, Alfred Hospital and Monash University, Melbourne, Victoria, Australia.
  • Flanagan KL; Department of Infectious Diseases, Monash Medical Centre, Melbourne, Victoria, Australia.
  • van de Sandt CE; School of Health Sciences and School of Medicine, University of Tasmania, Launceston, Tasmania, Australia.
  • Kedzierska K; Department of Immunology and Pathology, Monash University, Melbourne, Victoria, Australia.
  • McMahon JH; School of Health and Biomedical Science, RMIT University, Melbourne, Victoria, Australia; and.
  • Wheatley AK; Tasmanian Vaccine Trial Centre, Clifford Craig Foundation, Launceston General Hospital, Launceston, Tasmania, Australia.
  • Juno JA; Department of Microbiology and Immunology, University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia.
  • Kent SJ; Department of Microbiology and Immunology, University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia.
J Immunol ; 208(10): 2267-2271, 2022 05 15.
Article in English | MEDLINE | ID: covidwho-1835021
ABSTRACT
Understanding the generation of immunity to SARS-CoV-2 in lymphoid tissues draining the site of infection has implications for immunity to SARS-CoV-2. We performed tonsil biopsies under local anesthesia in 19 subjects who had recovered from SARS-CoV-2 infection 24-225 d previously. The biopsies yielded >3 million cells for flow cytometric analysis in 17 subjects. Total and SARS-CoV-2 spike-specific germinal center B cells, and T follicular helper cells, were readily detectable in human tonsils early after SARS-CoV-2 infection, as assessed by flow cytometry. Responses were higher in samples within 2 mo of infection but still detectable in some subjects out to 7 mo following infection. We conclude the tonsils are a secondary lymphoid organ that develop germinal center responses to SARS-CoV-2 infection and could play a role in the long-term development of immunity.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Limits: Humans Language: English Journal: J Immunol Year: 2022 Document Type: Article Affiliation country: Jimmunol.2101199

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Limits: Humans Language: English Journal: J Immunol Year: 2022 Document Type: Article Affiliation country: Jimmunol.2101199