[COVID-19-associated pulmonary aspergillosis in critically ill patients: experience of a Chilean public hospital]. / Aspergilosis pulmonar asociada a COVID-19 en pacientes críticos: experiencia de un hospital público chileno.
Rev Chilena Infectol
; 38(6): 754-760, 2021 12.
Article
in Spanish
| MEDLINE | ID: covidwho-1835030
ABSTRACT
BACKGROUND:
Aspergillus spp. fungal coinfections have been described in critically ill COVID-19 patients.AIM:
To describe the clinical characteristics, diagnosis, treatment and evolution of patients with acute respiratory distress syndrome with COVID-19, who present with COVID-19 associated pulmonary aspergillosis (CAPA) in a single public hospital.METHODS:
Retrospective review of clinical records during 12 months in patients diagnosed with CAPA by cultures of respiratory samples or determination of galactomannan (GM).RESULTS:
Probable CAPA was diagnosed in 11 patients (average APACHE II score of 11.7). Respiratory samples were obtained in 73% of cases by bronchoalveolar lavage and in 27% by tracheal aspirate. A. fumigatus was isolated in 4 cultures, A. niger, A. terreus and Aspergillus spp on one occasion each and the cultures were negative in 4 samples. Respiratory sample GM was performed in 7 patients, median 3.6 (IQR 1.71 - 4.4). In 10 patients, serum GM was performed, median 0.5 (IQR 0.265 - 0.9 75) with 50% of them > 0.5. Two patients showed classic findings suggestive of CAPA on computed tomography. All received antifungal therapy with voriconazole, mean time 14 days. Four patients died.CONCLUSIONS:
The presence of CAPA should be a diagnosis to be considered in critically ill COVID-19 patients.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Pulmonary Aspergillosis
/
Invasive Pulmonary Aspergillosis
/
COVID-19
Type of study:
Diagnostic study
/
Observational study
/
Prognostic study
Topics:
Long Covid
Limits:
Humans
Country/Region as subject:
South America
/
Chile
Language:
Spanish
Journal:
Rev Chilena Infectol
Year:
2021
Document Type:
Article
Affiliation country:
S0716-10182021000600754
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