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Ocular sequelae in severe COVID-19 recovered patients of second wave.
Dipu, Taw; Goel, Ruchi; Arora, Ritu; Thakar, Meenakshi; Gautam, Akanksha; Shah, Shalin; Gupta, Yashi; Chhabra, Mohit; Kumar, Sumit; Singh, Kirti; Kumar, Suresh; Garg, Sandeep; Singh, Harpreet; Pant, Rashmi.
  • Dipu T; Department of Ophthalmology, Guru Nanak Eye Centre, Maulana Azad Medical College, New Delhi, India.
  • Goel R; Department of Ophthalmology, Guru Nanak Eye Centre, Maulana Azad Medical College, New Delhi, India.
  • Arora R; Department of Ophthalmology, Guru Nanak Eye Centre, Maulana Azad Medical College, New Delhi, India.
  • Thakar M; Department of Ophthalmology, Guru Nanak Eye Centre, Maulana Azad Medical College, New Delhi, India.
  • Gautam A; Department of Ophthalmology, Guru Nanak Eye Centre, Maulana Azad Medical College, New Delhi, India.
  • Shah S; Department of Ophthalmology, Guru Nanak Eye Centre, Maulana Azad Medical College, New Delhi, India.
  • Gupta Y; Department of Ophthalmology, Guru Nanak Eye Centre, Maulana Azad Medical College, New Delhi, India.
  • Chhabra M; Department of Ophthalmology, Guru Nanak Eye Centre, Maulana Azad Medical College, New Delhi, India.
  • Kumar S; Department of Ophthalmology, Guru Nanak Eye Centre, Maulana Azad Medical College, New Delhi, India.
  • Singh K; Department of Ophthalmology, Guru Nanak Eye Centre, Maulana Azad Medical College, New Delhi, India.
  • Kumar S; Department of Medicine, Lok Nayak Hospital, Maulana Azad Medical College, New Delhi, India.
  • Garg S; Department of Medicine, Lok Nayak Hospital, Maulana Azad Medical College, New Delhi, India.
  • Singh H; Department of Medicine, Lok Nayak Hospital, Maulana Azad Medical College, New Delhi, India.
  • Pant R; Society for Health Education and Allied Research, New Delhi, India.
Indian J Ophthalmol ; 70(5): 1780-1786, 2022 05.
Article in English | MEDLINE | ID: covidwho-1835158
ABSTRACT

Purpose:

To evaluate the retinal microvascular changes in patients, recovered from severe COVID-19 during the second wave of the pandemic in North India.

Methods:

In this observational cross-sectional study, 70 eyes of 35 patients who recovered from severe COVID-19 during the second wave underwent detailed ophthalmic evaluation 4-6 weeks after discharge. Twelve controls were also enrolled, and the difference in the findings between the case and control groups on optical coherence tomography (OCTA) were studied.

Result:

The ages of study participants ranged from 27 to 60 years with the malefemale ratio being 1.051. The fundus changes suggestive of ischemia in the form of cotton wool spots and vascular tortuosity were seen in 25 eyes (35.71%). Increased venous tortuosity was the most common finding seen in 23 eyes (32.85%), of which 10 eyes (28.57%) had concurrent hypertensive retinopathy (HTR) changes. There was a significant reduction in the mean vascular density (VD) and perfusion density (PD) for both the superficial capillary plexus (SCP) and deep capillary plexus (DCP) at inner, outer ring, and whole (P < 0.05). Foveal avascular zone was significantly enlarged in both the SCP (P = 0.01) and the DCP (P = 0.03). The mean ganglion cell-inner plexiform layer (GC-IPL) was significantly reduced in comparison to controls (P < 0.001).

Conclusion:

Severe COVID-19 can result in microvascular changes at the macula in the form of reduction in vascular and perfusion density, which can be evaluated using OCTA. As structural changes precede functional changes, a close watch is recommended in patients showing compromise in retinal microvasculature.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 / Macula Lutea Type of study: Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Topics: Long Covid Limits: Adult / Female / Humans / Male / Middle aged Language: English Journal: Indian J Ophthalmol Year: 2022 Document Type: Article Affiliation country: Ijo.IJO_2882_21

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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 / Macula Lutea Type of study: Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Topics: Long Covid Limits: Adult / Female / Humans / Male / Middle aged Language: English Journal: Indian J Ophthalmol Year: 2022 Document Type: Article Affiliation country: Ijo.IJO_2882_21