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The cognitive basis of psychosocial impact in COVID-19 pandemic. Does it encircle the default mode network of the brain? A pragmatic proposal.
Dubey, Souvik; Dubey, Mahua Jana; Ghosh, Ritwik; Mitchell, Alex J; Chatterjee, Subhankar; Das, Shambaditya; Pandit, Alak; Ray, Biman Kanti; Das, Gautam; Benito-León, Julián.
  • Dubey S; Department of Neuromedicine, Bangur Institute of Neurosciences, Kolkata, India.
  • Dubey MJ; Department of Psychiatry, Berhampore Mental Hospital, Murshidabad, India.
  • Ghosh R; Department of General Medicine, Burdwan Medical College & Hospital, Burdwan, West Bengal, India.
  • Mitchell AJ; University Hospitals of Leicester, University of Leicester, Leicester, U.K.
  • Chatterjee S; Department of Medicine, RG Kar Medical College, and Hospital, Kolkata, West Bengal, India.
  • Das S; Department of Neuromedicine, Bangur Institute of Neurosciences, Kolkata, India.
  • Pandit A; Department of Neuromedicine, Bangur Institute of Neurosciences, Kolkata, India.
  • Ray BK; Department of Neuromedicine, Bangur Institute of Neurosciences, Kolkata, India.
  • Das G; Department of Neuromedicine, Bangur Institute of Neurosciences, Kolkata, India.
  • Benito-León J; Department of Neurology, University Hospital "12 de Octubre", Madrid, Spain.
Med Res Arch ; 10(3)2022 Mar.
Article in English | MEDLINE | ID: covidwho-1836118
ABSTRACT
Epigenetics, hypothalamic-pituitary axes, environmental and metabolic influences, and transgenerational plasticity govern social behavior. Cognitive research considers the brain's default mode network (DMN) as a central hub that integrates various cognitive and social processing domains responsible for emotion perception, empathy, theory of mind, and morality. Hence, DMN is regarded as the "social brain." Upsurge in social turmoil, social anxiety, panic, depression, post-traumatic stress, hoarding, herd behavior, substance and behavioral addictions, sexual abuse, and violence in the time of the COVID-19 pandemic are intricately related to personality traits resulting in disruptive social cognition and social behavior, conceptualized as the result of unsettling and disruption of the functional nexus of the DMN. Considering overt and conspicuous display of neuroticism during the current pandemic, its impact upon modulation of the DMN functional nexus and the DMN itself, and the potential to presage cognitive impairment in the future, the authors caution that an increase in the global burden of dementia may be one of the long-term ramifications of COVID-19. Social behavior, a functional derivative of the DMN, can strikingly affect the functional nexus of DMN and the DMN itself, in a centripetal way via the phenomenon called "Experience-Dependent Plasticity," with long-term consequences. In this review, we intend to 1) decipher the association between social cognition and social behavior with the DMN, in time of COVID-19; and to 2) discuss the prospective aftermath of disrupted social behavior during the pandemic on modulation/alteration of functional connectomes of DMN or the DMN itself in the time ahead.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Experimental Studies / Observational study / Prognostic study Topics: Long Covid Language: English Year: 2022 Document Type: Article Affiliation country: Mra.v10i3.2707

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Experimental Studies / Observational study / Prognostic study Topics: Long Covid Language: English Year: 2022 Document Type: Article Affiliation country: Mra.v10i3.2707