Cardiac biomarkers on admission and inhospital mortality in COVID-19 patients with or without concomitant heart failure.
Pol Arch Intern Med
; 132(7-8)2022 08 22.
Article
in English
| MEDLINE | ID: covidwho-1836208
ABSTRACT
INTRODUCTION:
Highsensitivity cardiac troponin T (hs-cTnT) and N-terminal pro-B type natriuretic peptide (NT proBNP) are known markers of cardiac injury. However, their role in predicting the severity of COVID19 remains to be investigated.OBJECTIVES:
We aimed to analyze the association between hscTnT and NT-proBNP levels and in hospital mortality in patients with COVID19, with emphasis on those with concomitant chronic heart failure (CHF). PATIENTS ANDMETHODS:
A total of 1729 consecutive patients with COVID19 were enrolled. Demographic data, laboratory parameters, and clinical outcomes (discharge or death) were analyzed. Receiver operating characteristic (ROC) and logistic regression analyses were performed to evaluate the association between hscTnT and NT-proBNP values and the risk of death.RESULTS:
Evaluation of hscTnT was performed in 1041 patients, while NT-proBNP was assessed in 715 individuals. CHF was present in 179 cases (10.4% of the cohort). Median values of hscTnT and NT-proBNP and inhospital mortality were higher in CHF patients than in those without CHF. Among patients without CHF, mortality was the highest in those with hscTnT or NT-proBNP values in the fourth quartile. In ROC analysis, hscTnT equal to or above 142 ng/l and NT-proBNP equal to or above 969 pg/ml predicted inhospital death. In patients without CHF, each 10-ng/l increase in hs-cTnT or 100-pg/ml increase in NTproBNP was associated with a higher risk of death (odds ratio [OR], 1.01 and OR, 1.02, respectively; P <0.01 for both).CONCLUSION:
The level of hscTnT or NT-proBNP predicts in hospital mortality in COVID-19 patients. Both hscTnT and NT-proBNP should be routinely measured on admission in all patients hospitalized due to COVID19 for early detection of individuals with an increased risk of in hospital death, even if they do not have concomitant heart failure.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
COVID-19
/
Heart Failure
Type of study:
Cohort study
/
Diagnostic study
/
Experimental Studies
/
Observational study
/
Prognostic study
Limits:
Humans
Language:
English
Year:
2022
Document Type:
Article
Affiliation country:
Pamw.16256
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