Modernizing Medical Research to Benefit People and Animals
Animals
; 12(9):1173, 2022.
Article
in English
| ProQuest Central | ID: covidwho-1837399
ABSTRACT
Simple SummaryThe use of animals in research has been the subject of significant public debate and concern. Some argue that animal experiments are essential to medical progress, while others believe that this practice is unethical and does not produce results that can be reliably translated to people. A growing range of modern techniques can replace the use of animals and provide results that are more relevant to human patients. These include the use of human cells and tissues, and computer-based methods. Our work aimed to explore the societal benefits of accelerating the replacement of animals with these new research methods. We found that this approach would benefit animal welfare, public health and the economy. We also found that the British public is generally in favor of efforts to replace animals, and that focusing on this area would help to support the British Government’s policy and economic goals. We suggest that the British Government could greatly expedite the replacement of animal experiments by appointing a new minister to take responsibility for this transition.In the context of widespread public and political concern around the use of animals in research, we sought to examine the scientific, ethical and economic arguments around the replacement of animals with New Approach Methodologies (NAMs) and to situate this within a regulatory context. We also analyzed the extent to which animal replacement aligns with British public and policymakers’ priorities and explored global progress towards this outcome. The global context is especially relevant given the international nature of regulatory guidance on the safety testing of new medicines. We used a range of evidence to analyze this area, including scientific papers;expert economic analysis;public opinion polls and the Hansard of the UK Parliament. We found evidence indicating that replacing animals with NAMs would benefit animal welfare, public health and the economy. The majority of the British public is in favor of efforts to replace animals and focusing on this area would help to support the British Government’s current policy priorities. We believe that this evidence underlines the need for strong action from policymakers to accelerate the transition from animal experiments to NAMs. The specific measure we suggest is to introduce a new ministerial position to coordinate and accelerate the replacement of animals with NAMs.
Veterinary Science; animal research; animal testing; alternative methods; animal replacement; New Approach Methodologies (NAMs); Economic analysis; Public health; Medical research; Artificial intelligence; Priorities; Scientific papers; Context; Animal welfare; Drugs; Public opinion; Metabolism; Ethics; Opinion polls; Laboratory animals; Alzheimers disease; COVID-19; Position measurement; Modernization; Gene expression; Animals; Experiments; Research methods; Coronaviruses; United Kingdom--UK
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Collection:
Databases of international organizations
Database:
ProQuest Central
Language:
English
Journal:
Animals
Year:
2022
Document Type:
Article
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