Bovine Aortic Arch: A Result of Chance or Mandate of Inheritance?
Am J Cardiol
; 172: 115-120, 2022 06 01.
Article
in English
| MEDLINE | ID: covidwho-1838526
ABSTRACT
Previous studies have shown that bovine arch incidence is higher in patients with thoracic aortic aneurysms than in patients without an aneurysm. Although thoracic aortic aneurysm disease is known to be familial in some cases, it remains unknown if bovine arch results from a genetic mutation, thus allowing it to be inherited. Our objective was to determine the heritability of bovine arch from phenotypic pedigrees. We identified 24 probands from an institutional database of 202 living patients with bovine arch who had previously been diagnosed with thoracic aortic aneurysm and who had family members with previous chest computed tomography or magnetic resonance imaging scans. Aortic arch configuration of all first-degree and second-degree relatives was determined from available scans. Heritability of bovine arch was estimated using maximum-likelihood-based variance decomposition methodology implemented by way of the SOLAR package (University of Maryland, Catonsville, Maryland). 43 relatives of 24 probands with bovine arch had preexisting imaging available for review. The prevalence of bovine arch in relatives with chest imaging was 53% (n = 23) and did not differ significantly by gender (male 64.3%, female 55.6%, p = 1). The bovine arch was shown to be highly heritable with a heritability estimate (h2) of 0.71 (p = 0.048). In conclusion, the high heritability of bovine arch in our sample population suggests a genetic basis.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Aortic Aneurysm, Thoracic
/
Aneurysm
Type of study:
Observational study
Topics:
Long Covid
/
Variants
Limits:
Female
/
Humans
/
Male
Language:
English
Journal:
Am J Cardiol
Year:
2022
Document Type:
Article
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