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Short Communication: S100A8 and S100A9, Biomarkers of SARS-CoV-2 Infection and Other Diseases, Suppress HIV Replication in Primary Macrophages.
Oguariri, Raphael M; Brann, Terrence W; Adelsberger, Joseph W; Chen, Qian; Goswami, Suranjana; Mele, Anthony R; Imamichi, Tomozumi.
  • Oguariri RM; Laboratory of Human Retrovirology and Immunoinformatics, Applied and Development Research Directorate, Frederick National Laboratory for Cancer Research, Frederick, Maryland, USA.
  • Brann TW; Laboratory of Human Retrovirology and Immunoinformatics, Applied and Development Research Directorate, Frederick National Laboratory for Cancer Research, Frederick, Maryland, USA.
  • Adelsberger JW; AIDS Monitoring Laboratory, Applied and Development Research Directorate, Frederick National Laboratory for Cancer Research, Frederick, Maryland, USA.
  • Chen Q; Laboratory of Human Retrovirology and Immunoinformatics, Applied and Development Research Directorate, Frederick National Laboratory for Cancer Research, Frederick, Maryland, USA.
  • Goswami S; Laboratory of Human Retrovirology and Immunoinformatics, Applied and Development Research Directorate, Frederick National Laboratory for Cancer Research, Frederick, Maryland, USA.
  • Mele AR; Laboratory of Human Retrovirology and Immunoinformatics, Applied and Development Research Directorate, Frederick National Laboratory for Cancer Research, Frederick, Maryland, USA.
  • Imamichi T; Laboratory of Human Retrovirology and Immunoinformatics, Applied and Development Research Directorate, Frederick National Laboratory for Cancer Research, Frederick, Maryland, USA.
AIDS Res Hum Retroviruses ; 38(5): 401-405, 2022 05.
Article in English | MEDLINE | ID: covidwho-1840021
ABSTRACT
S100A8 and S100A9 are members of the Alarmin family; these proteins are abundantly expressed in neutrophils, form a heterodimer complex, and are secreted in plasma on pathogen infection or acute inflammatory diseases. Recently, both proteins were identified as novel biomarkers of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and were shown to play key roles in inducing an aggressive inflammatory response by mediating the release of large amounts of pro-inflammatory cytokines, called the "cytokine storm." Although co-infection with SARS-CoV-2 in people living with HIV-1 may result in an immunocompromised status, the role of the S100A8/A9 complex in HIV-1 replication in primary T cells and macrophages is still unclear. Here, we evaluated the roles of the proteins in HIV replication to elucidate their functions. We found that the complex had no impact on virus replication in both cell types; however, the subunits of S100A8 and S100A9 inhibit HIV in macrophages. These findings provide important insights into the regulation of HIV viral loads during SARS-CoV-2 co-infection.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: HIV Infections / Coinfection / COVID-19 Type of study: Experimental Studies / Prognostic study Limits: Humans Language: English Journal: AIDS Res Hum Retroviruses Journal subject: SINDROME DA IMUNODEFICIENCIA ADQUIRIDA (AIDS) Year: 2022 Document Type: Article Affiliation country: AID.2021.0193

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Full text: Available Collection: International databases Database: MEDLINE Main subject: HIV Infections / Coinfection / COVID-19 Type of study: Experimental Studies / Prognostic study Limits: Humans Language: English Journal: AIDS Res Hum Retroviruses Journal subject: SINDROME DA IMUNODEFICIENCIA ADQUIRIDA (AIDS) Year: 2022 Document Type: Article Affiliation country: AID.2021.0193