Congenital and acquired defects of immunity: An ever-evolving story.
Pediatr Allergy Immunol
; 33 Suppl 27: 61-64, 2022 01.
Article
in English
| MEDLINE | ID: covidwho-1840509
ABSTRACT
Inborn errors of immunity (IEI), also referred to as primary immunodeficiencies (PID), are disorders that, for the most part, result from mutations in genes involved in immune host defense and immune regulation. With the increased availability of high-throughput DNA sequencing and improved genomic data interpretation, the number of newly identified genes associated with IEI has exponentially increased over the last decade. Here, we focus on the newly described IEI associated with severe COVID-19 and SASH3 deficiency, the most recently reported IEI with impaired T-cell receptor (TCR) signaling.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Primary Immunodeficiency Diseases
/
COVID-19
Limits:
Humans
Language:
English
Journal:
Pediatr Allergy Immunol
Journal subject:
Allergy and Immunology
/
Pediatrics
Year:
2022
Document Type:
Article
Affiliation country:
Pai.13632
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